诱导F1大鼠对亲代T细胞上抗主要组织相容性复合体受体产生耐受性。对自身耐受性的影响。
Induced tolerance in F1 rats to anti-major histocompatibility complex receptors on parental T cells. Implications for self tolerance.
作者信息
Bellgrau D, Smilek D, Wilson D B
出版信息
J Exp Med. 1981 Jun 1;153(6):1660-5. doi: 10.1084/jem.153.6.1660.
Abstract
The immunogenicity of cell surface markers associated with specific anti-major histocompatibility complex (MHC) alloreactivity of rat peripheral T lymphocyte subpopulations has been demonstrated in the past by the ability of such cell populations to induce a profound and specific resistance to systemic graft-vs.-host (GVH) disease in adult rats. Our studies demonstrate that these specificity-associated anti-MHC parental strain T cell markers are also tolerogenic; if small numbers of parental strain T cells are administered to newborn F1 rats, they result in the specific inability to induce GVH resistance later on in adult life. Moreover, unlike normal animals, these F1 rats are extremely sensitive to systemic GVH disease caused by T cells from the original donor parental strain.
摘要
过去已证明，大鼠外周血T淋巴细胞亚群与特异性抗主要组织相容性复合体（MHC）同种异体反应相关的细胞表面标志物具有免疫原性，这种细胞群体能够在成年大鼠中诱导对全身性移植物抗宿主（GVH）病的深刻而特异性的抵抗力。我们的研究表明，这些与特异性相关的抗MHC亲代菌株T细胞标志物也具有致耐受性；如果将少量亲代菌株T细胞给予新生F1大鼠，它们会导致成年后无法特异性诱导GVH抵抗力。此外，与正常动物不同，这些F1大鼠对来自原始供体亲代菌株的T细胞引起的全身性GVH病极为敏感。
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本文引用的文献
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Ann N Y Acad Sci. 1962 Oct 24;99:432-55. doi: 10.1111/j.1749-6632.1962.tb45326.x.
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Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
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Nat New Biol. 1971 Dec 8;234(49):178-80. doi: 10.1038/newbio234178a0.
7
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