T细胞受体的免疫学研究。I. 宿主针对同种异体反应性亲代T细胞的T细胞免疫介导的大鼠移植物抗宿主病特异性诱导抗性。
Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells.
作者信息
Bellgrau D, Wilson D B
出版信息
J Exp Med. 1978 Jul 1;148(1):103-14. doi: 10.1084/jem.148.1.103.
Abstract
The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T-cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients.
摘要
目前的研究扩展了我们之前的工作，以了解F1杂种大鼠中特异性诱导的移植物抗宿主（GVH）抗性的免疫基础。用亲代品系来源的同种异体反应性T细胞群体免疫F1大鼠，可诱导宿主介导的T细胞反应，该反应对亲代T细胞上的抗主要宿主相容性复合体受体具有特异性。这种保护性免疫起效迅速，一旦诱导产生，就能对致死性GVH疾病提供高效、特异性的抗性，这种抗性具有放射抗性，并且可以过继转移给同基因受体。
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Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells.T细胞受体的免疫学研究。I. 宿主针对同种异体反应性亲代T细胞的T细胞免疫介导的大鼠移植物抗宿主病特异性诱导抗性。
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The life-span and recirculation of marrow-derived small lymphocytes from the rat thoracic duct.大鼠胸导管中骨髓来源的小淋巴细胞的寿命和再循环
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Specific unresponsiveness of recirculating lymphocytes ater exposure to histocompatibility antigen in F 1 hybrid rats.F1杂种大鼠循环淋巴细胞在接触组织相容性抗原后出现的特异性无反应性。
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