Denis F, Saulnier M, Roger-Dalbert Y, Chiron J P, M'Boup S, Cadoz M, David-Prince M, Diop Mar I
Nouv Presse Med. 1981 Jul 4;10(29):2427-30.
The cerebrospinal fluids of 920 Senegalese patients with purulent meningitis wee examined by latex particle agglutination (LA) and the results were compared with those of conventional bacteriology and of counter immuno electro phoresis (C.I.E.). For all three organisms taken globally, CSF culture was positive in 72.7% of the patients, the LA test in 78.8% and the C.I.E. test in 89.0%. The LA test was positive in 17.9% of subjects with negative CSF culture. When the results wee analysed for each organism separately, the LA test was positive in 69.3%, 74.7% and 85.9% respectively of patients with meningococcal, pneumococcal and H. influenzae b meningitis. False agglutinations were found in 6.7% of meningitis due to other pathogens. Cross-reactions and autoagglutinations were rare (0.4% and 3.7% respectively). The sensitivity, specificity, simplicity and rapidity of the LA test make it extremely useful for the diagnosis of purulent meningitis, particularly in Africa.
对920例患有化脓性脑膜炎的塞内加尔患者的脑脊液进行了乳胶颗粒凝集试验（LA）检测，并将结果与传统细菌学检测及对流免疫电泳（C.I.E.）检测结果进行了比较。总体而言，对于所有三种病原体，脑脊液培养在72.7%的患者中呈阳性，LA检测在78.8%的患者中呈阳性，C.I.E.检测在89.0%的患者中呈阳性。在脑脊液培养阴性的患者中，LA检测在17.9%的受试者中呈阳性。当分别对每种病原体的结果进行分析时，LA检测在患有脑膜炎球菌性、肺炎球菌性和b型流感嗜血杆菌性脑膜炎的患者中分别有69.3%、74.7%和85.9%呈阳性。在由其他病原体引起的脑膜炎中，6.7%出现了假凝集。交叉反应和自身凝集很少见（分别为0.4%和3.7%）。LA检测的敏感性、特异性、简便性和快速性使其对化脓性脑膜炎的诊断极为有用，尤其是在非洲。
