Hudelson B, Liu J, Ocariz J, Martin D, Slater L M
Transplantation. 1981 Jun;31(6):449-51. doi: 10.1097/00007890-198106000-00010.
We wish to report strong lymphocyte crossmatch incompatibility attributable to anti-Lea antibody. The prospective renal transplant recipient was Le(a-b-) and her serum contained potent anti-Lea and anti-LebH antibodies. Despite the fact that were able to demonstrate greater B lymphocyte than T lymphocyte Lewis(a+) antigenicity, this serum was capable of causing greater than 80% cytotoxicity of Le(a+) and Le(b+)O or A2 whole lymphocyte populations. Antibody activity was completely inhibited by Lewis substance. This inhibition was specific and did not interfere with HLA antibody activity.
我们希望报告一例由抗-Lea抗体导致的强烈淋巴细胞交叉配型不相容的病例。这位预期的肾移植受者为Le(a-b-)型，其血清中含有强效的抗-Lea和抗-LebH抗体。尽管我们能够证明B淋巴细胞的Lewis(a+)抗原性强于T淋巴细胞，但这种血清能够导致Le(a+)和Le(b+)O型或A2型全淋巴细胞群体超过80%的细胞毒性。抗体活性被Lewis物质完全抑制。这种抑制是特异性的，并不干扰HLA抗体活性。
