Gehrz R C, Christianson W R, Linner K M, Conroy M M, McCue S A, Balfour H H
Am J Obstet Gynecol. 1981 Jul 15;140(6):665-70. doi: 10.1016/0002-9378(81)90201-5.
T-cell number and mitogen- and antigen-induced lymphocyte proliferative were assessed longitudinally in 18 normal human pregnancies to examine the effects of pregnancy on cellular immunity. The T-cell percentage and mitogen-induced responses did not change significantly in pregnant women as compared to nonpregnant, non-postpartum control adults. However, cell-mediated immune responses to three antigens were dramatically depressed during the third trimester and then returned to early pregnancy levels by 90 days post partum. This reduction in antigen-specific cellular immunity may be necessary to prevent rejection of the histoincompatible fetus by the mother and at the same time may render women in late gestation more susceptible to infection.
在18例正常人类妊娠中纵向评估T细胞数量以及丝裂原和抗原诱导的淋巴细胞增殖，以研究妊娠对细胞免疫的影响。与未怀孕、未产后的对照成年人相比，孕妇的T细胞百分比和丝裂原诱导反应没有显著变化。然而，在妊娠晚期，对三种抗原的细胞介导免疫反应显著降低，然后在产后90天恢复到妊娠早期水平。抗原特异性细胞免疫的这种降低可能是为了防止母亲排斥组织不相容的胎儿，同时可能使妊娠晚期的女性更容易感染。
