托萘酯对黄曲霉毒素生物合成的抑制作用。
Inhibition of aflatoxin biosynthesis by tolnaftate.
作者信息
Khan S N, Maggon K K, Venkitasubramanian T A
出版信息
Appl Environ Microbiol. 1978 Aug;36(2):270-3. doi: 10.1128/aem.36.2.270-273.1978.
Tolnaftate [2-napthyl-N-methyl-N-(m-tolyl)thionocarbamate], an antifungal drug, is widely used to control superficial fungal infections in humans and other animals. In this study the effect of tolnaftate on aflatoxin biosynthesis by Aspergillus parasiticus NRRL 3240 was investigated. Tolnaftate changed the morphology of A. parasiticus to yeastlike forms and inhibited aflatoxin formation. The formation of aflatoxin G was blocked considerably, indicating a metabolic block in the conversion of aflatoxin B to aflatoxin G. The incorporation of [1-14C]acetate into aflatoxin was significantly inhibited at a concentration of 1 mM tolnaftate. The presence of zinc in the resuspension buffer resulted in reversal of the tolnaftate-induced inhibition of aflatoxin G1 biosynthesis.
托萘酯[2-萘基-N-甲基-N-(间甲苯基)硫代氨基甲酸酯]是一种抗真菌药物，广泛用于控制人类和其他动物的浅表真菌感染。在本研究中，研究了托萘酯对寄生曲霉NRRL 3240黄曲霉毒素生物合成的影响。托萘酯使寄生曲霉的形态变为酵母样形式，并抑制黄曲霉毒素的形成。黄曲霉毒素G的形成被显著阻断，表明在黄曲霉毒素B向黄曲霉毒素G的转化过程中存在代谢阻断。在1 mM托萘酯浓度下，[1-14C]乙酸掺入黄曲霉毒素的过程被显著抑制。重悬缓冲液中锌的存在导致托萘酯诱导的黄曲霉毒素G1生物合成抑制作用的逆转。
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