2-巯基乙醇对黄曲霉毒素形成的抑制作用。
Inhibition of aflatoxin formation by 2-mercaptoethanol.
作者信息
Gupta S K, Maggon K K, Venkitasubramanian T A
出版信息
Appl Environ Microbiol. 1976 Sep;32(3):324-6. doi: 10.1128/aem.32.3.324-326.1976.
Abstract
2-Mercaptoethanol inhibits growth of Aspergillus parasiticus NRRL 3240 and aflatoxin formation by the fungus. When added to the resuspended medium, 2-mercaptoethanol inhibited [1-14C]acetate incorporation into both aflatoxins and neutral lipids, thereby showing that it acts at an early stage of aflatoxin biosynthesis. The inhibition is probably due to its chelating action on zinc, which is essential for aflatoxin production. It is proposed that any chelating agent that selectively binds to zinc will inhibit aflatoxin formation.
摘要
2-巯基乙醇可抑制寄生曲霉NRRL 3240的生长及该真菌的黄曲霉毒素形成。当添加至重悬培养基中时，2-巯基乙醇可抑制[1-14C]乙酸掺入黄曲霉毒素和中性脂质中，从而表明其作用于黄曲霉毒素生物合成的早期阶段。这种抑制作用可能是由于其对锌的螯合作用，而锌对于黄曲霉毒素的产生至关重要。有人提出，任何能选择性结合锌的螯合剂都会抑制黄曲霉毒素的形成。
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引用本文的文献
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2
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J Biol Chem. 1966 Oct 10;241(19):4406-10.
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Production of aflatoxin B 1 from defined natural cultures of Aspergillus flavus (Link).由黄曲霉（Link.）特定自然培养物产生黄曲霉毒素B1 。
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