Weinberg D S, Pinkus G S
Am J Clin Pathol. 1981 Aug;76(2):190-6. doi: 10.1093/ajcp/76.2.190.
Recently, the authors described a distinct variant of T-cell lymphoma characterized morphologically by large multilobated nuclei, and clinically by a predilection for extranodal sites and a favorable prognosis. In a retrospective study of 75 cases of "histiocytic" lymphomas observed during a 13-year period, ten additional cases of this unusual variant of non-Hodgkin's lymphoma were identified. Features similar to those of the initial group of cases included a predominant extranodal distribution, particularly involving skin, subcutaneous tissue, and bone, and a favorable response to therapy. However, the retrospective cases differed in that systemic symptoms were infrequent and gonadal involvement was not observed. Recognition of this morphologically distinct subtype of non-Hodgkin's lymphoma is of diagnostic, therapeutic, and prognostic significance.
最近，作者描述了一种T细胞淋巴瘤的独特变体，其形态学特征为细胞核大且多叶，临床特征为倾向于结外部位且预后良好。在一项对13年间观察到的75例“组织细胞性”淋巴瘤的回顾性研究中，又发现了10例这种非霍奇金淋巴瘤的不寻常变体病例。与最初一组病例相似的特征包括主要为结外分布，尤其累及皮肤、皮下组织和骨骼，以及对治疗反应良好。然而，回顾性病例的不同之处在于全身症状不常见，且未观察到性腺受累。认识到这种形态学上独特的非霍奇金淋巴瘤亚型具有诊断、治疗和预后意义。
