Palva T, Tolvanen E, Konttinen Y T, Reitamo S
Arch Otolaryngol. 1981 Sep;107(9):528-31. doi: 10.1001/archotol.1981.00790450004003.
Middle ear mucosal biopsy specimens were taken from 12 patients with chronic otitis media. The specimens from 11 cases contained enough inflammatory cells for a detailed study of the inflammatory cell subtypes in the lamina propria. T lymphocytes, mononuclear phagocytes, and plasma cells were the most frequent cell types except in two patients, in whom most of the inflammatory lymphocytes were B lymphocytes. The relative scarcity of B lymphocytes could be caused by activation and transformation to plasma cells. The close contact between different immunocompetent cells suggests T- and B-cell interactions. However, pseudolymphoid transformation with primary and secondary lymphatic follicles was observed in only one patient. The relative scarcity of granulocytes in the submucosal infiltrate could be caused by the movement of these cells through the epithelium into the discharge.
从12例慢性中耳炎患者身上获取中耳黏膜活检标本。11例患者的标本含有足够的炎症细胞，可用于详细研究固有层中的炎症细胞亚型。除两名患者外，T淋巴细胞、单核吞噬细胞和浆细胞是最常见的细胞类型，在这两名患者中，大多数炎症淋巴细胞是B淋巴细胞。B淋巴细胞相对较少可能是由于其激活并转化为浆细胞所致。不同免疫活性细胞之间的紧密接触表明存在T细胞和B细胞相互作用。然而，仅在一名患者中观察到伴有初级和次级淋巴滤泡的假淋巴瘤样转化。黏膜下浸润中粒细胞相对较少可能是由于这些细胞穿过上皮进入分泌物中。
