Pecori Vettori L, Cecchi L, Costanzo A, Auzzi G, Bruni F
Farmaco Sci. 1981 Jun;36(6):441-8.
2-Phenylpryrazolo [1,5-a]pyrimidine (I) 4,7-dihydro-2-phenylpyrazolo [1,5-a]pyrimidin-7-one (II) and 4,5-dihydro-2-phenylpyrazolo [1,5-a]pyrimidin-5-one (III) are prepared. Because of the interesting antipyretic, hypothermizing and anti-inflammatory properties of some of their derivatives, the above mentioned compounds are used as reference compounds in a Q.S.A.R. study still in progress. Methylation of (II) and (III) with (CH3)2SO4 and CH2N2 gives methylderivatives whose structure is determined by spectroscopic means.
制备了2-苯基吡唑并[1,5-a]嘧啶（I）、4,7-二氢-2-苯基吡唑并[1,5-a]嘧啶-7-酮（II）和4,5-二氢-2-苯基吡唑并[1,5-a]嘧啶-5-酮（III）。由于它们某些衍生物具有有趣的解热、降温及抗炎特性，上述化合物在一项仍在进行的定量构效关系（Q.S.A.R.）研究中用作参考化合物。用硫酸二甲酯（(CH3)2SO4）和重氮甲烷（CH2N2）对（II）和（III）进行甲基化反应，得到甲基衍生物，其结构通过光谱手段确定。
