Libshitz H I, Edeiken B S
AJR Am J Roentgenol. 1981 Sep;137(3):585-8. doi: 10.2214/ajr.137.3.585.
Significant radiation-induced abnormalities (aseptic necrosis of the femoral heads, slipped capital femoral epiphysis, radiation-induced sarcoma) were identified in eight of 44 patients aged 16 years or younger at the time of radiotherapy and followed for at least 3 years. The incidence is 18% in the entire group and 25% (8/32) if only patients with radiographs of the hips 3 or more years after therapy are considered. The first evidence of abnormality developed 13 years after irradiation in one patient. The need for long term follow-up of therapeutically irradiated children is stressed.
在44例放疗时年龄为16岁及以下且随访至少3年的患者中,发现了8例显著的辐射诱发异常(股骨头无菌性坏死、股骨头骨骺滑脱、辐射诱发肉瘤)。整个组的发病率为18%,如果仅考虑治疗后3年或更长时间有髋部X光片的患者,发病率为25%(8/32)。一名患者在放疗13年后出现了异常的首个证据。强调了对接受治疗性放疗的儿童进行长期随访的必要性。