Ruben F L, Thompson D S
Am J Obstet Gynecol. 1981 Oct 15;141(4):443-7. doi: 10.1016/0002-9378(81)90609-8.
Samples of cord blood from 46 deliveries were collected between 2 and 8 mo after an epidemic of influenza caused by A/Port Chalmers/73 (H3H2) virus. Of 10 samples with HAI antibody titers against A/Port Chalmers of 1:16 or greater, one had 2-mercaptoethanol-sensitive IgM class antibodies against the virus. Lymphocyte proliferative responses with the use of A/Port Chalmers antigens were increased in six of 46 samples. These results provide immunologic evidence that certain neonates have IgM antibodies and lymphocytes sensitized for influenza A virus. Our results suggest, but do not prove definitively, that influenza A/Port Chalmers virus infected the fetus prior to delivery.
在由A/查尔姆斯港/73（H3H2）病毒引起的流感流行后的2至8个月期间，收集了46例分娩的脐带血样本。在10份针对A/查尔姆斯港的血凝抑制（HAI）抗体效价为1:16或更高的样本中，有一份含有针对该病毒的2-巯基乙醇敏感IgM类抗体。在46份样本中的6份中，使用A/查尔姆斯港抗原时淋巴细胞增殖反应增强。这些结果提供了免疫学证据，表明某些新生儿具有针对甲型流感病毒的IgM抗体和致敏淋巴细胞。我们的结果表明，但不能确凿证明，甲型流感A/查尔姆斯港病毒在分娩前感染了胎儿。
