T细胞可能表现出多种活性：一种克隆的T细胞系可表现出特异性同种辅助、细胞溶解和迟发型超敏反应。
T cells may express multiple activities: specific allohelp, cytolysis, and delayed-type hypersensitivity are expressed by a cloned T-cell line.
作者信息
Dennert G, Weiss S, Warner J F
出版信息
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4540-3. doi: 10.1073/pnas.78.7.4540.
Abstract
A T-cell line that recognizes private specificities encoded in the H-2 IA subregion in the proliferative response, cytotoxic activity, delayed-type hypersensitivity, and allohelp reaction with B cells has been cloned. The individual clones were assayed for ability to express the activities of the parent line. Results show that the cloned sublines tested are able to perform all the activities of the parent line. It is suggested that T cells may express multiple activities and that the apparent monofunctionality of T cells is due to regulation of these activities.
摘要
已克隆出一种T细胞系，该细胞系在增殖反应、细胞毒性活性、迟发型超敏反应以及与B细胞的同种辅助反应中，能够识别由H-2 IA亚区编码的个体特异性。对各个克隆进行了检测，以确定其表达亲代细胞系活性的能力。结果表明，所测试的克隆亚系能够执行亲代细胞系的所有活性。这表明T细胞可能表达多种活性，并且T细胞明显的单功能性是由于这些活性的调节所致。
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