Gu S Q, Ros A M, von Stedingk L V, Thyresson N, Wasserman J
Int Arch Allergy Appl Immunol. 1981;66(4):372-81. doi: 10.1159/000232846.
T-lymphocyte subpopulations and pokeweed mitogen(PWM)-induced immunoglobulin (Ig) synthesis of mononuclear cells in vitro were studied in patients with psoriasis as well as in age- and sex-matched normal blood donors. The frequences of T cells with receptors for IgG (Tg) and T cells with receptors for IgM (Tm) were examined. The IgG and IgM synthesis in mononuclear cell suspensions in the presence of different amounts of PWM was determined. The percentage of total T cells (rosetting with neuroaminidase-treated sheep red blood cells), including high and low affinity T lymphocytes showed no difference between the patient group and controls. The patients with psoriasis had a significantly higher mean proportion of Tg cells than the normal donors whereas there was no significant difference in the proportions of Tm cells between these two groups. The PWM-induced Ig synthesis in the mononuclear cell suspension seemed lower in patients with psoriasis than in controls, the difference being statistically significant when the results were expressed as ratios of Ig amounts present in the supernatants of PWM-stimulated and non-stimulated cultures (index of stimulation).
对银屑病患者以及年龄和性别匹配的正常献血者进行了研究，观察了体外T淋巴细胞亚群以及商陆有丝分裂原（PWM）诱导的单核细胞免疫球蛋白（Ig）合成情况。检测了具有IgG受体的T细胞（Tg）和具有IgM受体的T细胞（Tm）的频率。测定了在不同量PWM存在下单核细胞悬液中IgG和IgM的合成。包括高亲和力和低亲和力T淋巴细胞在内的总T细胞（与神经氨酸酶处理的绵羊红细胞形成玫瑰花结）百分比在患者组和对照组之间没有差异。银屑病患者的Tg细胞平均比例明显高于正常献血者，而两组之间Tm细胞比例没有显著差异。银屑病患者单核细胞悬液中PWM诱导的Ig合成似乎低于对照组，当结果以上清液中PWM刺激和未刺激培养物中Ig含量的比值（刺激指数）表示时，差异具有统计学意义。
