Bodger M P, Francis G E, Delia D, Granger S M, Janossy G
J Immunol. 1981 Dec;127(6):2269-74.
An anti-human monoclonal antibody (RFB-1) has been produced that reacts with a group of hemopoietic precursor cells in human bone marrow. These include terminal deoxynucleotidyl transferase-positive (TdT+) cells and myeloid colony-forming unit cells, functionally identifiable progenitor cells of the granulocytic-monocytic series. The expression of RFB-1 antigen on myeloid cells decreases as the cells become more mature; myeloblasts are weakly RFB-1+ but most promyelocytes are RFB-1-. RFB-1 also reacts with TdT+ thymic blast cells and cortical thymocytes but is unreactive with TdT- medullary thymocytes, although the majority of peripheral T cells are weakly RFB-1+. RFB-1 is the first anti-precursor cell reagent that labels human TdT+ cells in both the thymus and bone marrow as well as hemopoietic precursor cells but is unreactive with pre-B blasts and B lymphocytes.
已制备出一种抗人单克隆抗体（RFB - 1），它可与人类骨髓中的一组造血前体细胞发生反应。这些细胞包括末端脱氧核苷酸转移酶阳性（TdT +）细胞和髓系集落形成单位细胞，它们是粒细胞 - 单核细胞系列功能上可识别的祖细胞。随着髓系细胞变得更加成熟，RFB - 1抗原在其上的表达会降低；原粒细胞为弱RFB - 1阳性，但大多数早幼粒细胞为RFB - 1阴性。RFB - 1也可与TdT +胸腺母细胞和皮质胸腺细胞发生反应，但与TdT - 髓质胸腺细胞无反应，尽管大多数外周T细胞为弱RFB - 1阳性。RFB - 1是第一种抗前体细胞试剂，它可标记胸腺和骨髓中的人类TdT +细胞以及造血前体细胞，但与前B母细胞和B淋巴细胞无反应。
