Yano Y, Cahoon J L, Budinger T F
J Nucl Med. 1981 Nov;22(11):1006-10.
A precision flow-controlled rubidium-82 generator has been constructed to deliver 76-sec Rb-82 at either fast or slow flow rates for bolus or constant-infusion studies. A stepping motor drive is interfaced to a microprocessor for pulsed control of flow rate to deliver the saline eluant solution from a large-volume (150 ml) machined pumping syringe through an alumina column that retains the 25-day Sr-82 parent. The generator system delivers 70-90% of the maximum Rb-82 activity in a 20-25 ml bolus elution of 2% NaCl. The Sr-82/Sr-85 breakthrough is 10(-7) - 10(-6). both yield and breakthrough are functions of column length and flow rate. Six separate Sr-82 loadings of the generator were evaluated over a period of nearly 2 yr in studies of myocardial blood perfusion and permeability changes in the blood-brain barrier. Sterility and apyrogenicity of the Rb-82 eluate were maintained during multiple elutions and long-term use of 3-4 mo for each generator loading.
已构建了一台精密流量控制的铷 - 82发生器，可在快速或慢速流速下提供76秒的铷 - 82，用于团注或持续输注研究。步进电机驱动器与微处理器相连，用于脉冲控制流速，以便将盐水洗脱液从大容量（150毫升）加工的注射泵通过一个保留25天半衰期锶 - 82母体的氧化铝柱输送出去。该发生器系统在20 - 25毫升2%氯化钠的团注洗脱中可提供最大铷 - 82活度的70 - 90%。锶 - 82/锶 - 85的穿透率为10^(-7) - 10^(-6)。产率和穿透率都是柱长和流速的函数。在近2年的时间里，对该发生器进行了6次单独的锶 - 82装载，用于心肌血流灌注和血脑屏障通透性变化的研究。在多次洗脱以及每个发生器装载3 - 4个月的长期使用过程中，铷 - 82洗脱液的无菌性和无热原性均得以保持。
