Yano Y, Budinger T F, Chiang G, O'Brien H A, Grant P M
J Nucl Med. 1979 Sep;20(9):961-6.
Generator-produced Rb-82, a 75-sec positron emitter with potential for myocardial blood-flow imaging, was studied with various ion-exchange columns to evaluate the characteristics of alumina as an adsorber for the 25-day Sr-82 parent. Test columns of alumina, Bio Rex 70, and Chelex 100 were loaded with multimillicurie amounts of no-carrier-added Sr-82/Sr-85 (Sr-85 is a production contaminant). The breakthrough of Sr-82/Sr-85, and the yield of Rb-82, were determined for long-term elutions from each column with up to 4 liter of 2% NaCl solution at pH 8 to 9. The breakthrough of Sr-82/85 was 10(-6)-10(-5) from aluminal 10(-6)-10(-4) from Chelex 100 and Bio Rex 70. The effects of eluent flow rate and concentration, and of alumina volume, on the breakthrough and yield were also studied. An improved and automated Rb-82 generator was used for myocardial and brain blood-flow studies in experimental animals and in man; it was equipped with solenoid flow-control valves and five in. of lead shielding for the alumina columns, which were charged with 25-50 mCi Sr-82 (100-150 mCi Sr-85). The Rb-82 generator with alumina column provided up to 20-40 mCi of Rb-82 as often as every 5-10 min with less than 10(-5) breakthrough of Sr-82/85 over the 2- to 3-mo, useful life of the generator.
用各种离子交换柱研究了发生器产生的Rb-82，它是一种半衰期为75秒的正电子发射体，具有用于心肌血流成像的潜力，以评估氧化铝作为25天母体Sr-82吸附剂的特性。用无载体添加的Sr-82/Sr-85（Sr-85是生产中的污染物）的多毫居里量装填氧化铝、Bio Rex 70和Chelex 100测试柱。用高达4升pH值为8至9的2%氯化钠溶液对每个柱进行长期洗脱，测定Sr-82/Sr-85的穿透率和Rb-82的产率。氧化铝柱上Sr-82/85的穿透率为10^(-6)-10^(-5)，Chelex 100和Bio Rex 70柱上为10^(-6)-10^(-4)。还研究了洗脱液流速和浓度以及氧化铝体积对穿透率和产率的影响。一种改进的自动化Rb-82发生器用于实验动物和人体的心肌和脑血流研究；它配备了电磁流量控制阀和5英寸厚的铅屏蔽层用于氧化铝柱，柱中装填25-50毫居里的Sr-82（100-150毫居里的Sr-85）。装有氧化铝柱的Rb-82发生器每5-10分钟可提供高达20-40毫居里的Rb-82，在发生器2至3个月的使用寿命内，Sr-82/85的穿透率小于10^(-5)。
