Gallagher P, Vose B M, Moore M, Schofield P F
Gut. 1982 Jan;23(1):31-5. doi: 10.1136/gut.23.1.31.
The T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.
对T淋巴细胞介导的自体结肠癌细胞杀伤作用进行了研究。患者病情进展、年龄或营养状况对活性发生率均无影响，从血液、引流淋巴结或肿瘤本身提取的淋巴细胞之间也未显示出差异。然而，T淋巴细胞活性似乎对患者自身的肿瘤具有特异性，因为在同种异体肿瘤中很少观察到。其也与淋巴细胞自然杀伤活性无关。体外研究表明，47例结肠癌患者中有23例存在患者特异性T淋巴细胞活性，但结果与临床和病理发现无关。
