乳腺肿瘤的巨噬细胞浸润：一项前瞻性研究。
Macrophage infiltration of breast tumours: a prospective study.
作者信息
Lauder I, Aherne W, Stewart J, Sainsbury R
出版信息
J Clin Pathol. 1977 Jun;30(6):563-8. doi: 10.1136/jcp.30.6.563.
Abstract
In 50 cases of infiltrating breast cancer investigated in a prospective study the number of macrophages within each tumour was assessed. The macrophages were identified by their cytoplasmic acid phosphatase activity. The number of lymphocytes and plasma cells within the tumours were graded by a scoring technique. Significantly fewer cases with metastases were found among those with high macrophage and plasma cell scores. There was no correlation between lymphoreticular infiltration and the degree of tumour differentiation, but in cases without metastases the lymphoreticular infiltration between tumour cells was nearly always only slight when the macrophage score was low.
摘要
在一项前瞻性研究中，对50例浸润性乳腺癌患者进行了调查，评估了每个肿瘤内巨噬细胞的数量。巨噬细胞通过其细胞质酸性磷酸酶活性来识别。肿瘤内淋巴细胞和浆细胞的数量通过评分技术进行分级。在巨噬细胞和浆细胞评分高的患者中，发生转移的病例明显较少。淋巴网状浸润与肿瘤分化程度之间没有相关性，但在无转移的病例中，当巨噬细胞评分较低时，肿瘤细胞之间的淋巴网状浸润几乎总是很轻微。
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本文引用的文献
1
LATE RESULTS OF OPERATION FOR CARCINOMA OF THE BREAST.乳腺癌手术的远期结果
Ann Surg. 1927 Nov;86(5):695-701.
2
Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes.乳腺癌病例的生存情况与原发肿瘤及区域淋巴结结构的关系。
Surg Gynecol Obstet. 1955 May;100(5):543-51.
3
Cytochemical study of esterase activity of human neoplasms and stromal macrophages.人类肿瘤及基质巨噬细胞酯酶活性的细胞化学研究
Cancer. 1961 Mar-Apr;14:369-77. doi: 10.1002/1097-0142(196103/04)14:2<369::aid-cncr2820140217>3.0.co;2-x.
4
Inflammation and prognosis in breast cancer; a search for host resistance.乳腺癌中的炎症与预后；对宿主抵抗力的探索。
Cancer. 1959 Jul-Aug;12(4):714-20. doi: 10.1002/1097-0142(195907/08)12:4<714::aid-cncr2820120414>3.0.co;2-b.
5
Histochemical demonstration of acid phosphatases with naphthol AS-phosphates.用萘酚AS-磷酸盐进行酸性磷酸酶的组织化学显示。
J Natl Cancer Inst. 1958 Sep;21(3):523-39.
6
Possible host resistance in carcinoma of the breast: a histological study.乳腺癌中可能存在的宿主抵抗力：一项组织学研究。
Br J Cancer. 1968 Sep;22(3):383-401. doi: 10.1038/bjc.1968.47.
7
Cooperation of immune lymphoid cells with macrophages in tumour immunity.免疫淋巴细胞与巨噬细胞在肿瘤免疫中的协同作用。
Nature. 1970 Nov 14;228(5272):620-2. doi: 10.1038/228620a0.
8
Local immunoglobulin production in breast cancer.乳腺癌中的局部免疫球蛋白产生
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Virchows Arch B Cell Pathol. 1972;12(1):39-50. doi: 10.1007/BF02893984.
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