Brown R C, Cooke J, Losowsky M S
Postgrad Med J. 1981 Mar;57(665):189-90. doi: 10.1136/pgmj.57.665.189.
A 45-year-old woman developed polyarthralgia and muscle tenderness after 6 months' therapy with labetalol 1800 mg daily. A raised ANF titre but normal DNA binding levels suggested a drug-induced SLE syndrome. Both symptoms and ANF titre improved when therapy was changed from labetalol to propranolol.
一名45岁女性在每日服用1800毫克拉贝洛尔治疗6个月后出现多关节痛和肌肉压痛。抗核因子(ANF)滴度升高但DNA结合水平正常,提示为药物性系统性红斑狼疮综合征。当治疗从拉贝洛尔改为普萘洛尔时,症状和ANF滴度均有所改善。