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1
B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.B细胞辅助因子。I. 白细胞介素2和另一种40,000道尔顿分子量因子的需求。
J Exp Med. 1981 Nov 1;154(5):1681-93. doi: 10.1084/jem.154.5.1681.
2
B cell helper factors. II. Synergy among three helper factors in the response of T cell- and macrophage-depleted B cells.B细胞辅助因子。II. 三种辅助因子在T细胞和巨噬细胞缺陷的B细胞应答中的协同作用。
J Immunol. 1982 Oct;129(4):1398-402.
3
Concanavalin A-induced human lymphocyte mitogenic factor: activity distinct from interleukin 1 and 2.伴刀豆球蛋白A诱导的人淋巴细胞促有丝分裂因子：不同于白细胞介素1和2的活性
J Immunol. 1982 Jul;129(1):56-62.
4
Helper signals in the plaque-forming cell response to protein-bound haptens.对蛋白质结合半抗原的空斑形成细胞反应中的辅助信号。
J Exp Med. 1983 Aug 1;158(2):317-33. doi: 10.1084/jem.158.2.317.
5
Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.伴刀豆球蛋白A诱导的、产生白细胞介素-2的T细胞杂交瘤
J Exp Med. 1980 Oct 1;152(4):893-904. doi: 10.1084/jem.152.4.893.
6
The role of interleukin-2 (IL-2) in the differentiatin of cytotoxic T cells: the effect of monoclonal anti-IL-2 antibody and absorption with IL-2 dependent T cell lines.白细胞介素-2（IL-2）在细胞毒性T细胞分化中的作用：单克隆抗IL-2抗体的作用及用IL-2依赖型T细胞系进行吸附的效果
J Immunol. 1981 Oct;127(4):1323-8.
7
A requirement for nonspecific T cell factors in antibody responses to "T cell independent" antigens.对“T细胞非依赖性”抗原产生抗体反应时非特异性T细胞因子的需求。
J Immunol. 1983 Feb;130(2):781-4.
8
Separable helper factors support B cell proliferation and maturation to Ig secretion.可分离的辅助因子支持B细胞增殖并成熟为分泌免疫球蛋白的细胞。
J Immunol. 1982 Aug;129(2):469-74.
9
Lymphokines and aging: interleukin-2 production and activity in aged animals.淋巴细胞因子与衰老：老年动物白细胞介素-2的产生及活性
J Immunol. 1981 Nov;127(5):2102-6.
10
Positively selected Lyt-2+ and Lyt-2- mouse T lymphocytes are comparable, after Con A stimulation, in release of IL 2 and of lymphokines acting on B cells, macrophages, and mast cells, but differ in interferon production.在伴刀豆球蛋白A刺激后，经阳性选择的Lyt-2⁺和Lyt-2⁻小鼠T淋巴细胞在白细胞介素2以及作用于B细胞、巨噬细胞和肥大细胞的淋巴因子释放方面相当，但在干扰素产生方面存在差异。
J Immunol. 1983 May;130(5):2225-30.

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1
Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep.骨桥蛋白：一种用于猪和羊植入的主要候选黏附分子。
J Anim Sci Biotechnol. 2014 Dec 17;5(1):56. doi: 10.1186/2049-1891-5-56. eCollection 2014.
2
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.信号转导和转录激活因子3（STAT3）介导的B淋巴细胞诱导成熟蛋白1（BLIMP1）上调与B细胞淋巴瘤/白血病-6（BCL6）下调协同作用，以控制人浆细胞分化。
J Immunol. 2008 Apr 1;180(7):4805-15. doi: 10.4049/jimmunol.180.7.4805.
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An adenoviral vector for probing promoter activity in primary immune cells.一种用于探测原代免疫细胞中启动子活性的腺病毒载体。
J Immunol Methods. 2006 Apr 20;311(1-2):19-30. doi: 10.1016/j.jim.2006.01.009. Epub 2006 Feb 20.
4
Fever and immunoregulation: hyperthermia, interleukins 1 and 2, and T-cell proliferation.发热与免疫调节：热疗、白细胞介素1和2以及T细胞增殖。
Yale J Biol Med. 1982 Sep-Dec;55(5-6):437-42.
5
Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.从一个克隆的T细胞系产生B细胞生长促进活性物质（DL）BCGF及其对BCL1 B细胞肿瘤的检测
J Exp Med. 1982 Dec 1;156(6):1821-34. doi: 10.1084/jem.156.6.1821.
6
Antigen-specific human T-cell hybridomas with helper activity.具有辅助活性的抗原特异性人T细胞杂交瘤。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6646-50. doi: 10.1073/pnas.79.21.6646.
7
A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion.一种单克隆T细胞替代活性可直接作用于B细胞以增强克隆扩增。
J Exp Med. 1982 Jul 1;156(1):306-11. doi: 10.1084/jem.156.1.306.
8
Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.对控制小鼠细胞毒性T淋巴细胞反应的增殖和分化信号的剖析。
J Exp Med. 1982 Jun 1;155(6):1876-81. doi: 10.1084/jem.155.6.1876.
9
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.
10
Interleukins for B lymphocytes.针对B淋巴细胞的白细胞介素。
Surv Immunol Res. 1983;2(3):210-2. doi: 10.1007/BF02918413.

本文引用的文献

1
Induction and suppression of polyclonal antibody responses by anti-Ig reagents and antigen-nonspecific helper factors: a comparison of the effects of anti-Fab, anti-IgM, and anti IgD on murine B cells.抗Ig试剂和抗原非特异性辅助因子对多克隆抗体反应的诱导与抑制：抗Fab、抗IgM和抗IgD对小鼠B细胞作用的比较
Immunol Rev. 1980;52:115-39. doi: 10.1111/j.1600-065x.1980.tb00333.x.
2
Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.伴刀豆球蛋白A诱导的、产生白细胞介素-2的T细胞杂交瘤
J Exp Med. 1980 Oct 1;152(4):893-904. doi: 10.1084/jem.152.4.893.
3
Purification to apparent homogeneity of murine interleukin 1.将小鼠白细胞介素1纯化至表观均一性。
J Immunol. 1981 Mar;126(3):834-7.
4
Specificity of cytotoxic T cells from athymic mice.无胸腺小鼠细胞毒性T细胞的特异性
J Exp Med. 1980 Sep 1;152(3):688-702. doi: 10.1084/jem.152.3.688.
5
Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines.淋巴细胞调节分子的生化特性。II. 一类大鼠和人类淋巴因子的纯化。
J Immunol. 1980 Apr;124(4):1954-62.
6
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
7
T cell-dependent mediator in the immune response. II. Physical and biological properties.免疫反应中T细胞依赖性介质。II. 物理和生物学特性。
Immunology. 1974 Jul;27(1):53-64.
8
A micro-technique for hemolytic plaque assays.一种用于溶血空斑测定的微量技术。
J Immunol. 1974 Mar;112(3):1271-4.
9
A third signal in B cell activation given by TRF.由TRF提供的B细胞激活中的第三种信号。
Transplant Rev. 1975;23:176-88. doi: 10.1111/j.1600-065x.1975.tb00157.x.
10
Functional heterogeneity among the T-derived lymphocytes of the mouse. II. Sensitivity of subpopulations to anti-thymocyte serum.小鼠T衍生淋巴细胞的功能异质性。II. 亚群对抗胸腺细胞血清的敏感性。
J Immunol. 1975 Feb;114(2 pt 2):747-51.

B细胞辅助因子。I. 白细胞介素2和另一种40,000道尔顿分子量因子的需求。

B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.

作者信息

Leibson H J, Marrack P, Kappler J W

出版信息

J Exp Med. 1981 Nov 1;154(5):1681-93. doi: 10.1084/jem.154.5.1681.

DOI:10.1084/jem.154.5.1681
PMID:6795304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186529/
Abstract

A helper factor(s) distinct from interleukin 2 (IL-2) was shown to be present in the concanavalin A-stimulated supernatant of normal mouse spleen cells (normal Con A Sn). Spleen cells thoroughly depleted of T cells required both IL-2 and this factor to produce antibody-secreting cells in response to sheep erythrocytes, although in the presence of IL-2 and a few T cells the requirement for the factor was less apparent. The factor had an apparent approximately 40,000 mol wt. The factor was found in normal Con A Sn that had been depleted of IL-2 by absorption with IL-2-dependent T cells and was absent from Con A-stimulated supernatants of the IL-2-producing T cell hybridoma, FS6-14.13. These results indicate that multiple helper factors control the B cell response to antigen and that IL-2, in addition to its T cell growth promoting activity, plays a direct role in B cell responses.

摘要

一种不同于白细胞介素2（IL-2）的辅助因子被证明存在于正常小鼠脾细胞经刀豆蛋白A刺激后的上清液（正常Con A Sn）中。彻底去除T细胞的脾细胞在对绵羊红细胞产生抗体分泌细胞时，既需要IL-2也需要这种因子，不过在有IL-2和少量T细胞存在的情况下，对该因子的需求不太明显。该因子的表观分子量约为40,000道尔顿。在通过与依赖IL-2的T细胞吸附而去除了IL-2的正常Con A Sn中发现了该因子，而在产生IL-2的T细胞杂交瘤FS6-14.13经刀豆蛋白A刺激后的上清液中则不存在。这些结果表明多种辅助因子控制B细胞对抗原的反应，并且IL-2除了其促进T细胞生长的活性外，在B细胞反应中也起直接作用。