Bjelle A, Cedergren B, Dahlqvist S R
Scand J Rheumatol. 1982;11(1):23-6. doi: 10.3109/03009748209098109.
The frequency of HLA B27 in blood donors born in northern Sweden was found to be 16.6%. This was significantly higher than in southern Sweden or in caucasians generally, with the exception of Finland. A close genetic relationship has been found between the population of northern Sweden and the Finnish. The higher frequency of HLA B27 is particularly interesting in view of the finding of a higher incidence of rheumatic diseases in northern than in southern Sweden. We also found a surprisingly large number of patients with reactive arthritides and ankylosing spondylitis in the patient registers of the rheumatology department, which further indicated a genetic influence on rheumatic disorders in northern Sweden.
在瑞典北部出生的献血者中，HLA B27的频率为16.6%。这一比例显著高于瑞典南部或一般白种人，芬兰除外。瑞典北部人口与芬兰人之间存在密切的遗传关系。鉴于瑞典北部风湿性疾病的发病率高于南部，HLA B27的较高频率尤其令人关注。我们还在风湿病科的患者登记册中发现了数量惊人的反应性关节炎和强直性脊柱炎患者，这进一步表明遗传因素对瑞典北部的风湿性疾病有影响。
