Delamere J P, Scott D L, Felix-Davies D D
J R Soc Med. 1982 Feb;75(2):102-6.
Musculoskeletal symptoms developing during the treatment of thyroid disease were studied in 150 patients; 17 developed a symptom complex of early morning stiffness together with shoulder girdle pain and weakness; similar symptoms were seen in only 3 of 100 controls. A prospective study of 16 patients with recent onset rheumatoid arthritis followed during the first 6 months of penicillamine therapy showed no changes in thyroid function tests. It is suggested that changing or abnormal thyroid status may precipitate or exacerbate musculoskeletal disease. Finally, in a retrospective study of 26 patients with both thyroid disease and rheumatoid arthritis, 4 patients had a simultaneous onset of both myxoedema and rheumatoid arthritis, the activity of which was greatly improved by correction of the hypothyroid state.
对150例甲状腺疾病患者在治疗期间出现的肌肉骨骼症状进行了研究；17例出现了包括晨僵、肩带疼痛和无力的症状复合体；100名对照者中只有3例出现了类似症状。对16例近期发病的类风湿关节炎患者在青霉胺治疗的前6个月进行的前瞻性研究显示，甲状腺功能测试无变化。提示甲状腺状态的改变或异常可能促使或加重肌肉骨骼疾病。最后，在一项对26例同时患有甲状腺疾病和类风湿关节炎患者的回顾性研究中，4例患者同时出现黏液性水肿和类风湿关节炎，通过纠正甲状腺功能减退状态，类风湿关节炎的活动度得到了显著改善。
