Hedges T R, Albert D M
Ophthalmology. 1982 Feb;89(2):165-77. doi: 10.1016/s0161-6420(82)34842-3.
The ocular pathologic findings from nine patients who suffered from herpes zoster ophthalmicus are described. Autopsy material from four patients who died within weeks of the illness and ocular specimens from five patients who required surgery for complications of the disease months to years later demonstrated how the ocular abnormalities caused by zoster may progress in severity with time. The changes ranged from superficial keratitis and mild uveitis to severe granulomatous inflammation of the ciliary body, choroid, and optic nerve within the first several weeks of the disease. In some instances damage secondary to vasculitis predominated, and in others inflammation directly involved ocular tissue. In some chronically affected eyes, granulomatous reaction to Descemet's membrane persisted for years, whereas in others the inflammatory reaction apparently resolved, allowing successful penetrating keratoplasty to be performed in one case.
本文描述了9例眼部带状疱疹患者的眼部病理检查结果。4例在患病数周内死亡患者的尸检材料，以及5例在疾病发生数月至数年后因并发症接受手术患者的眼部标本，展示了带状疱疹引起的眼部异常如何随时间推移而加重。疾病最初几周内，病变范围从浅层角膜炎和轻度葡萄膜炎到睫状体、脉络膜和视神经的严重肉芽肿性炎症。在某些情况下，血管炎继发损伤占主导，而在其他情况下，炎症直接累及眼部组织。在一些长期受影响的眼睛中，对Descemet膜的肉芽肿反应持续数年，而在其他眼睛中，炎症反应明显消退，其中1例成功进行了穿透性角膜移植术。
