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Pregnancy specific beta 1-glycoprotein (SP1) conversion of SP1 beta to SP1 alpha by "acidification": an artefact.

作者信息

Teisner B, Grudzinskas J G

出版信息

Arch Gynecol. 1982;231(2):141-7. doi: 10.1007/BF02111666.

DOI:10.1007/BF02111666
PMID:6978684
Abstract

Late pregnancy serum and plasma were examined in rocket immunoelectrophoresis (RIE) and crossed immunoelectrophoresis (XIE) before and after "acid treatment" (pH 2.5, 10 min). The analysis revealed changes in the precipitation morphology in the majority of circulating proteins extending from the albumin to the gamma-region. In RIE, the precipitation pattern of SP1 was altered, this change being independent of polyethylene glycol. In addition, XIE analysis of SP1 revealed a change in the precipitation morphology with no change in electrophoretic mobility. The results can be explained by non-specific aggregation and denaturation due to "acid treatment", and are therefore unlikely to be of any biological or immunochemical importance.

摘要

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本文引用的文献

1
On molecular heterogeneity of pregnancy specific beta 1-glycoprotein.关于妊娠特异性β1-糖蛋白的分子异质性
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Immunochemical and biological studies on two molecular variants of pregnancy specific beta 1 glycoprotein (SP1) SP1 alpha and SP1 beta.妊娠特异性β1糖蛋白（SP1）的两种分子变体SP1α和SP1β的免疫化学与生物学研究。
Clin Chim Acta. 1980 Sep 8;106(1):1-7. doi: 10.1016/0009-8981(80)90368-x.
3
Investigations into the molecular heterogeneity of pregnancy-specific beta 1-glycoprotein (SP1).
Placenta. 1981 Jul-Sep;2(3):233-40. doi: 10.1016/s0143-4004(81)80006-9.
4
Separation of two pregnancy-associated proteins with SP1 determinants and the conversion of SP1 beta to SP1 alpha.
Arch Gynecol. 1980;230(2):95-108. doi: 10.1007/BF02108265.
5
The ratio between molecular variants of pregnancy-specific beta 1 glycoprotein (SP1) in the peripheral and retroplacental circulation during later pregnancy.妊娠晚期外周血与胎盘后循环中妊娠特异性β1糖蛋白（SP1）分子变体之间的比例。
Placenta. 1980 Jul-Sep;1(3):223-6. doi: 10.1016/s0143-4004(80)80004-x.
6
Specific assay for pregnancy-specific-beta 1-glycoprotein (Sp1-beta). Preparation of antiserum specific for SP1-beta by absorption with a crossreacting high molecular weight serum protein.妊娠特异性β1-糖蛋白（Sp1-β）的特异性检测。通过与交叉反应的高分子量血清蛋白吸收来制备针对SP1-β的抗血清。
J Reprod Immunol. 1979 Oct;1(3):159-66. doi: 10.1016/0165-0378(79)90016-0.
7
Characterization of two pregnancy associated serum proteins with pregnancy specific beta 1-glycoprotein (PS-beta-G)-determinants.两种具有妊娠特异性β1-糖蛋白（PS-β-G）决定簇的妊娠相关血清蛋白的特性分析。
Scand J Clin Lab Invest. 1979 Jun;39(4):351-9. doi: 10.3109/00365517909106119.
8
Molecular heterogeneity of pregnancy specific beta 1 glycoprotein: the effect on measurement by radioimmunoassay and electroimmunoassay.妊娠特异性β1糖蛋白的分子异质性：对放射免疫测定和免疫电泳测定的影响。
J Immunol Methods. 1979;31(1-2):141-9. doi: 10.1016/0022-1759(79)90294-1.
9
Quantification of the pregnancy-specific beta1-glycoprotein (SP1) by immunoprecipitation techniques: the influence of a cross-reacting high molecular weight alpha2-protein.采用免疫沉淀技术对妊娠特异性β1-糖蛋白（SP1）进行定量分析：一种交叉反应性高分子量α2-蛋白的影响。
Scand J Immunol. 1979;9(5):409-17. doi: 10.1111/j.1365-3083.1979.tb03063.x.
10
Two pregnancy-associated serum proteins with pregnancy-specific beta1-glycoprotein determinants.两种具有妊娠特异性β1-糖蛋白决定簇的妊娠相关血清蛋白。
Am J Obstet Gynecol. 1978 Jun 1;131(3):262-6. doi: 10.1016/0002-9378(78)90597-5.