Grudzinskas J G, Teisner B, Chard T
Placenta. 1980 Jul-Sep;1(3):223-6. doi: 10.1016/s0143-4004(80)80004-x.
The ratio between two molecular variants of pregnancy-specific beta 1 glycoprotein (SP1) in the peripheral and retroplacental circulation was analysed in nine women during late pregnancy. The ratio between the two molecular variants, i.e. SP1 beta and SP1 alpha, was found to be identical in the peripheral and retroplacental circulation in all women examined. Comparisons were also made between SP1 beta as measured by radioimmunoassay and a normal serum protein, alpha 2 macroglobulin. A positive concentration gradient from peripheral to retroplacental circulation was found for SP1 beta whereas the gradient was less pronounced for alpha 2 macroglobulin. These findings add weight to the concept that SP1 alpha is a unique molecular species and not a genetic variant or a product of SP1 beta.
在妊娠晚期，对9名女性外周血和胎盘后循环中妊娠特异性β1糖蛋白（SP1）的两种分子变体之间的比例进行了分析。在所检查的所有女性中，外周血和胎盘后循环中两种分子变体，即SP1β和SP1α之间的比例是相同的。还对放射免疫法测定的SP1β与正常血清蛋白α2巨球蛋白进行了比较。发现SP1β在外周血到胎盘后循环中存在正浓度梯度，而α2巨球蛋白的梯度则不太明显。这些发现进一步支持了SP1α是一种独特的分子种类，而不是遗传变体或SP1β的产物这一概念。
