Aloia J F, Ostuni J A, Yeh J K, Zaino E C
Arch Intern Med. 1982 Apr;142(4):831-2.
A 17-year-old girl with thalassemia major experienced tetany. The serum calcium level was 5.5 mg/dL, and the phosphorus level was 6.3 mg/dL. Serum levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25-OHD) were subnormal at 125 pg/mL and 8.1 ng/mL, respectively, As a result of these findings, serum 25-OHD and PTH levels were measured in an additional 12 patients with thalassemia major. Low levels of both 25-OHD and PTH were found frequently. An increase in serum 25-OHD levels was noted in each of four patients who were examined after iron chelation therapy.
一名17岁的重型地中海贫血女孩出现了手足搐搦。血清钙水平为5.5mg/dL，磷水平为6.3mg/dL。甲状旁腺激素（PTH）和25-羟基维生素D（25-OHD）的血清水平分别为125pg/mL和8.1ng/mL，均低于正常水平。基于这些发现，又对另外12例重型地中海贫血患者检测了血清25-OHD和PTH水平。结果发现，25-OHD和PTH水平低的情况很常见。在接受铁螯合治疗后接受检查的4例患者中，每例患者的血清25-OHD水平均有升高。
