Lauria F, Pulvirenti A, Raspadori D, Tura S
Boll Ist Sieroter Milan. 1981 Nov;60(5):417-20.
In 16 normal subjects who underwent splenectomy for traumatic reasons, the T-lymphocyte number (E rosette positive cells) and the proportion of T-cell subsets were assessed on peripheral blood T-lymphocytes. The findings, compared with not splenectomised normal controls, showed other than an increase in the absolute number of T-lymphocytes, mainly a significant increase of T gamma cells (21% +/- 5 vs 13% +/- 4) and a less marked decrease of T mu cells (38.7% +/- 7 vs 51.8% +/- 12). Probably this increase in T gamma cells is irrelevant on the immune response and represents only the effect of the redistribution of T-cell subsets after splenectomy. Alternatively, splenectomy, removing most of the lymphocytes that respond to antigenic stimulation, and, producing an increase in T gamma cells, may contribute to the development of an impaired B-cell response and sometimes to the development of severe infections which occur mainly in splenectomised children.
在16名因外伤原因接受脾切除术的正常受试者中，对外周血T淋巴细胞的T淋巴细胞数量（E玫瑰花结阳性细胞）和T细胞亚群比例进行了评估。与未行脾切除术的正常对照组相比，结果显示除T淋巴细胞绝对数量增加外，主要是Tγ细胞显著增加（21%±5对13%±4），而Tμ细胞有较轻微的减少（38.7%±7对51.8%±12）。Tγ细胞的这种增加可能与免疫反应无关，仅代表脾切除术后T细胞亚群重新分布的效应。或者，脾切除术去除了大部分对抗原刺激有反应的淋巴细胞，并导致Tγ细胞增加，这可能导致B细胞反应受损的发展，有时还会导致主要发生在脾切除儿童中的严重感染的发展。
