Brooks D A, Bradley J, Zola H
Pathology. 1982 Jan;14(1):5-11. doi: 10.3109/00313028209069036.
A monoclonal antibody, FMC 8, has been prepared after immunization with a cell line of the non-T-non-B type acute lymphoblastic leukaemia (ALL). The antigen detected by this antibody consists of a single polypeptide chain with an apparent molecular weight of 24,000 d. The antigen is absent from T cells but appears after mitogen stimulation. It is found on the majority of normal circulating B cells but is absent in most chronic lymphocytic leukaemias. All cells of the non-T-non-B type express the antigen, whereas T-ALL cells generally do not. Granulocytes, monocytes and platelets react with the antibody, but erythrocytes do not. The wide but selective distribution of the antigen renders FMC 8 potentially useful, together with other monoclonal antibodies, in the delineation of differentiation pathways and in phenotypic analysis of leukaemia and lymphoma cells.
用非T非B型急性淋巴细胞白血病（ALL）细胞系免疫后制备了一种单克隆抗体FMC 8。该抗体检测到的抗原由一条表观分子量为24,000 d的单多肽链组成。T细胞中不存在该抗原，但在有丝分裂原刺激后出现。在大多数正常循环B细胞上可发现该抗原，但在大多数慢性淋巴细胞白血病中不存在。非T非B型的所有细胞均表达该抗原，而T-ALL细胞通常不表达。粒细胞、单核细胞和血小板与该抗体发生反应，但红细胞不反应。该抗原广泛但具有选择性的分布使得FMC 8与其他单克隆抗体一起，在白血病和淋巴瘤细胞的分化途径描绘及表型分析中具有潜在用途。
