Jovcić G S, Stojanović N N, Hajduković S I, Petrović N V
Cell Tissue Kinet. 1982 May;15(3):285-93. doi: 10.1111/j.1365-2184.1982.tb01048.x.
The effect of leucophoretic serum (LS), obtained from rats with polyvinylpyrrolidone (PVP)-induced inflammation, on granulopoiesis in the bone marrow of normal CBA mice was studied. The following test systems were used: short term cultures (4 hr), diffusion chambers (8, 24, 48 and 72 hr) and in vivo assays (12, 24 and 48 hr). The results indicate that LS stimulates the proliferations of granulocytic cells by increasing the number of proliferative granulocytes in mitosis, as well as increasing the total number of proliferative granulocytes. LS did not appear to effect monocytes and other cell lines. It is concluded that a factor present in LS specifically stimulates the proliferation of granulocytic cells, both in vitro and in vivo.
研究了从聚乙烯吡咯烷酮（PVP）诱导炎症的大鼠中获得的白细胞电泳血清（LS）对正常CBA小鼠骨髓粒细胞生成的影响。使用了以下测试系统：短期培养（4小时）、扩散盒（8、24、48和72小时）和体内试验（12、24和48小时）。结果表明，LS通过增加有丝分裂中增殖性粒细胞的数量以及增殖性粒细胞的总数来刺激粒细胞的增殖。LS似乎对单核细胞和其他细胞系没有影响。得出的结论是，LS中存在的一种因子在体外和体内均能特异性刺激粒细胞的增殖。
