B淋巴细胞亚群模式及其在特发性肾小球肾炎中的意义。
B lymphocyte subset patterns and their significance in idiopathic glomerulonephritis.
作者信息
Tani Y, Kida H, Abe T, Tomosugi N, Saito Y, Asamoto T, Hattori N
出版信息
Clin Exp Immunol. 1982 Apr;48(1):201-4.
The proportion of B lymphocyte subsets with surface immunoglobulin G (sIgG) was significantly increased in minimal change nephrotic syndrome (MCNS), membranous nephropathy, IgA nephropathy and mesangiocapillary glomerulonephritis (MCGN) and with sIgA in IgA nephropathy and MCGN, and with sIgE in MCNS. Increased subsets in membranous nephropathy, IgA nephropathy and MCGN corresponded to the immunoglobulins deposited in the glomeruli, and the increased subset of sIgE in MCNS was correlated with the elevation of serum IgE. These results suggest that each disease studied has a characteristic subset pattern of B lymphocyte response. This may have an important role in determining the histological type of idiopathic glomerulonephritis.
在微小病变型肾病（MCNS）、膜性肾病、IgA肾病和系膜毛细血管性肾小球肾炎（MCGN）中，表面免疫球蛋白G（sIgG）阳性的B淋巴细胞亚群比例显著增加；在IgA肾病和MCGN中，表面免疫球蛋白A（sIgA）阳性的B淋巴细胞亚群比例增加；在MCNS中，表面免疫球蛋白E（sIgE）阳性的B淋巴细胞亚群比例增加。膜性肾病、IgA肾病和MCGN中增加的亚群与肾小球中沉积的免疫球蛋白相对应，而MCNS中sIgE增加的亚群与血清IgE升高相关。这些结果表明，所研究的每种疾病都有其特征性的B淋巴细胞反应亚群模式。这可能在确定特发性肾小球肾炎的组织学类型方面发挥重要作用。
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