Schwartz R H, Rodriguez W J, Khan W N, Brigham L, Ross S
Clin Pediatr (Phila). 1982 Jul;21(7):402-4. doi: 10.1177/000992288202100703.
Cefaclor was used to treat 13 children with acute otitis media caused by ampicillin-resistant strains of Hemophilus influenzae. The children were re-examined on days 4, 10, and 28. Pharmacologic compliance was assessed by means of a bioinhibition assay on a urine specimen obtained on days 4, 7, and 10. Nine of the 13 children had evidence by tympanogram of residual otitis media with effusion (secretory otitis media). Of these, three were noted to have a bulging, yellow or grey eardrum, which suggested an ongoing acute process. A second middle ear culture was obtained from two of the 3 children, but no pathogens were recovered. Two others had recurrence of otitis shortly after cessation of therapy. Cefaclor is an acceptable antibiotic for the treatment of ampicillin-resistant acute otitis media; but, after cefaclor therapy, some children continued to have a bulging eardrum and sterile pus in the middle ear or had recurrences of otitis soon after cessation of therapy.
头孢克洛用于治疗13例由耐氨苄西林的流感嗜血杆菌菌株引起的急性中耳炎患儿。在第4天、第10天和第28天对患儿进行复查。通过对在第4天、第7天和第10天采集的尿液标本进行生物抑制试验来评估药物依从性。13例患儿中有9例经鼓室图检查有中耳积液残留（分泌性中耳炎）的证据。其中，3例患儿鼓膜膨出，呈黄色或灰色，提示急性病程仍在持续。从这3例患儿中的2例再次采集了中耳培养物，但未培养出病原体。另外2例患儿在治疗停止后不久中耳炎复发。头孢克洛是治疗耐氨苄西林急性中耳炎的一种可接受的抗生素；但是，在头孢克洛治疗后，一些患儿的鼓膜仍持续膨出，中耳有无菌性脓液，或者在治疗停止后不久中耳炎复发。
