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产后进行性遗传性内耳疾病中血管纹的特定病理学

Specific pathology of the stria vascularis in postnatal progressive genetic inner ear disorder.

作者信息

Anniko M

出版信息

Hear Res. 1982 Apr;6(3):247-58. doi: 10.1016/0378-5955(82)90058-2.

DOI:10.1016/0378-5955(82)90058-2
PMID:6979536
Abstract

After reaching normal morphological maturation the stria vascularis of the Shaker-2 (Sh-2) mouse postnatally underwent a progressive degeneration, especially of the intermediate cell layer. Considerable changes were present on the 3rd week after birth. The marginal cells became atrophic and showed a reduction in the number and extent of the cellular extensions towards the intermediate cell layer. The intermediate cells disintegrated but were present 9 weeks after birth. The basal cells showed a normal morphology. Specific inclusion bodies were identified in the marginal cells from the 3rd week on. Occasionally such inclusions occurred in marginal cells. In the Shaker-1 (Sh-1) a flattening of intermediate cells occurred but otherwise no pathological changes were found 6--9 weeks after birth.

摘要

达到正常形态成熟后,Shaker-2(Sh-2)小鼠的血管纹在出生后经历了渐进性退化,尤其是中间细胞层。出生后第3周出现了相当大的变化。边缘细胞萎缩,向中间细胞层延伸的细胞数量和范围减少。中间细胞解体,但在出生后9周仍存在。基底细胞形态正常。从第3周开始在边缘细胞中发现了特异性包涵体。偶尔,这种包涵体也出现在边缘细胞中。在Shaker-1(Sh-1)中,中间细胞出现扁平现象,但在出生后6至9周未发现其他病理变化。

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