Schroff R W, Foon K A
Blood. 1982 Aug;60(2):373-80.
Heterogeneity of leukemic cells was defined in a case of lymphoma. Four phenotypically distinct subpopulations of leukemic cells were identified. One subpopulation was observed to simultaneously express B- and T-cell characteristics. B-cell characteristics included monoclonal IgM (lambda) surface immunoglobulin, HLA-DR antigens, and expression of the B-cell antigen identified by the BA-1 monoclonal antibody. T-cell characteristics included E-rosette formation, expression of the pan-T-associated antigens recognized by the Leu-1 and OKT-11 monoclonal antibodies, and expression of the suppressor cytotoxic T-cell-associated antigen recognized by the Leu-2 and OKT-8 monoclonal antibodies. In addition to this subpopulation, three other phenotypically distinct subpopulations were identified, two of which expressed monoclonal IgM (lambda) surface immunoglobulin. The results of this investigation indicates that three phenotypically distinct lymphoid subpopulations bearing B-cell characteristics, and probably a fourth T-cell subgroup, were derived from a common lineage. These findings suggest that the malignancy involved a lymphoid progenitor cell that may possess diverse maturational capacity.
在一例淋巴瘤病例中确定了白血病细胞的异质性。鉴定出白血病细胞的四个表型不同的亚群。观察到一个亚群同时表达B细胞和T细胞特征。B细胞特征包括单克隆IgM（λ）表面免疫球蛋白、HLA-DR抗原以及由BA-1单克隆抗体鉴定的B细胞抗原的表达。T细胞特征包括E花环形成、由Leu-1和OKT-11单克隆抗体识别的泛T相关抗原的表达以及由Leu-2和OKT-8单克隆抗体识别的抑制性细胞毒性T细胞相关抗原的表达。除了这个亚群外，还鉴定出另外三个表型不同的亚群，其中两个表达单克隆IgM（λ）表面免疫球蛋白。这项研究结果表明，三个具有B细胞特征的表型不同的淋巴亚群，可能还有第四个T细胞亚群，源自一个共同的谱系。这些发现提示该恶性肿瘤涉及一个可能具有多种成熟能力的淋巴祖细胞。
