[源自阿尔萨斯的精神分裂症患者中HLA - A、C和Bf抗原的频率（作者译）]

[Frequencies of HLA-A, C and Bf antigens in schizophrenic patients originated from Alsace (author's transl)].

作者信息

Singer L, Mayer S, Tongio M M, Roos M, Danion J M, Bernard H, Leclercq P, Hauptmann G, Kapfer M T, Bindler J, Mandel P

出版信息

Encephale. 1982;8(1):9-15.

Abstract

A comparison of the frequency of HLA-A, B, C and Bf antigens observed in a group of 75 chronic schizophrenics and in a control group of 184, all strictly from Alsace, does not carry any argument in favour of a strong genetic association between schizophrenia and the antigens studied. In effect, the modifications observed in the schizophrenic sample--decrease in the frequency of A10 and B5 antigens, and increase of A29 and BfF--are not statistically significant when the probabilities are multiplied by the number of tested antigens. These preliminary results however do not permit to exclude the possibility of an association between schizophrenia and the tested antigens.

摘要

对一组75名慢性精神分裂症患者以及184名均严格来自阿尔萨斯地区的对照组人员进行HLA - A、B、C和Bf抗原频率比较，结果并未发现任何证据支持精神分裂症与所研究抗原之间存在强遗传关联。实际上，在精神分裂症样本中观察到的变化——A10和B5抗原频率降低，以及A29和BfF频率升高——当概率乘以所检测抗原的数量时，在统计学上并不显著。然而，这些初步结果并不能排除精神分裂症与所检测抗原之间存在关联的可能性。