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[精神分裂症与人类白细胞抗原]

[Schizophrenia and HLA antigens].

作者信息

Barocci S, Roccatagliata G, Maffini M, Costantini M

出版信息

Schweiz Arch Neurol Neurochir Psychiatr. 1981;129(1):31-5.

PMID:7313593
Abstract

38 schizophrenic patients (21 hebephrenics and 17 paranoids) and 124 healthy subjects were matched for HLA antigens. HLA typing was determined by the microdroplet lymphocyte toxicity method developed by Terasaki of UCLA. In order to detect 47 HLA antigens as many as 118 antisera were used. No significant differences in HLA typing were found between the two groups. However, the separate evaluation of HLA antigens of hebephrenic schizophrenics did not give any statistical significance, as well. The authors discuss these findings in the light of previous studies on the topic.

摘要

38名精神分裂症患者(21名青春型精神分裂症患者和17名偏执型精神分裂症患者)和124名健康受试者进行了HLA抗原匹配。HLA分型采用加州大学洛杉矶分校的寺崎开发的微量淋巴细胞毒性法测定。为了检测47种HLA抗原,使用了多达118种抗血清。两组之间在HLA分型上未发现显著差异。然而,对青春型精神分裂症患者的HLA抗原进行单独评估也未得出任何统计学意义。作者根据此前关于该主题的研究对这些发现进行了讨论。

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