Goudemand M, Goudemand J, Parquet P J, Fontan M
Encephale. 1981;7(5):609-22.
Genetic factors play probably an important part in the development of schizophrenic psychoses. As a consequence the use of a genetic marker as the HLA system appears to be interesting in determining the disease susceptibility gene of these psychoses. Methods and results of an investigation about the frequencies of 33 HLA alleles observed in 51 patients considered as paranoid schizophrenics are presented. The frequency of HLA-A 29 was diminished while the one of HLA-B 15 was increased but the differences were no longer significant when p was corrected. However when all the results published from 1974 to 1980 were pooled in a combined statistical analysis, some associations became significant. It seems that schizophrenia as a whole, once paranoid and hebephrenic sub-types have to be distinguished. It may be concluded from these data that correlations between schizophrenia and HLA antigens which remain doubtful could be explained with a biological genetic heterogeneity of schizophrenic disorders. Review of literature concerning the identification of HLA haplotypes in schizophrenics pedigrees and about the HLA system as a genetic marker for the clinical response to neuroleptics in schizophrenic patients or in vitro, is also discussed.
遗传因素可能在精神分裂症性精神病的发病过程中起重要作用。因此，使用像HLA系统这样的遗传标记来确定这些精神病的疾病易感基因似乎很有意义。本文介绍了对51例偏执型精神分裂症患者中观察到的33种HLA等位基因频率进行调查的方法和结果。HLA - A29的频率降低，而HLA - B15的频率升高，但校正p值后差异不再显著。然而，当将1974年至1980年发表的所有结果进行综合统计分析时，一些关联变得显著。似乎总体上精神分裂症，一旦偏执型和青春型亚型得以区分。从这些数据可以得出结论，精神分裂症与HLA抗原之间尚存疑问的相关性，可能可用精神分裂症性障碍的生物遗传异质性来解释。还讨论了关于在精神分裂症患者家系中鉴定HLA单倍型以及HLA系统作为精神分裂症患者对神经阻滞剂临床反应或体外反应的遗传标记的文献综述。
