[精神分裂症：偏执型与人类白细胞抗原A9和B5的关联]

[Schizophrenia: association of the paranoid form and antigens HLA-A9 and B5].

作者信息

Mercier P, Sutter J M, Julien R A, Kieffer N

出版信息

Encephale. 1977;3(1):49-53.

Abstract

30 unrelated Schizophrenic patients (15 Hebephrenic and 15 Paranoïd forms) were Typed for 14 A and 16 B Specificities by microlymphocytotoxicity. We note: 10 (5H + 5P) HLA--A1 (33.3 % / controls 23.4 %) 5 (2H + 3P) HLA--A3 (16.6 % / controls 26.2 %) 6 (5H + 1P) HLA--B8, 0 HLA--B27, 0 HLA BW16 and more specially: 10 (3H + 7P) HLA--A9 (23 + 24) 8 (2H + 6P) HLA--B5 These two last antigens are more often found in the Paranoïd patients of whom 46.6% are A9 Tcontrols: 24 %) and 40 % are B5 (controls 13.2 %. The Pc values are not significant in these too short seria but the strongly increased frequencies of A9 and B5 in the Paranoïd group seem to open a new biological aspect in the nosographic distinction of the Schizophrenia and so confirm previous results of C. L. CAZZULLO et al.

摘要

通过微量淋巴细胞毒性试验，对30例无亲缘关系的精神分裂症患者（15例青春型和15例偏执型）进行了14种A抗原和16种B抗原分型。我们注意到：10例（5例青春型+5例偏执型）HLA - A1（33.3%/对照组23.4%）；5例（2例青春型+3例偏执型）HLA - A3（16.6%/对照组26.2%）；6例（5例青春型+1例偏执型）HLA - B8，0例HLA - B27，0例HLA BW16，更特别的是：10例（3例青春型+7例偏执型）HLA - A9（23 + 24）；8例（2例青春型+6例偏执型）HLA - B5。这后两种抗原在偏执型患者中更常见，其中46.6%为A9（对照组：24%），40%为B5（对照组13.2%）。在这些样本量过小的系列研究中，Pc值无统计学意义，但偏执型组中A9和B5频率的显著增加似乎为精神分裂症的疾病分类学区分开启了一个新的生物学视角，从而证实了C. L. 卡祖洛等人先前的研究结果。