甲状腺功能亢进和减退时的儿茶酚胺敏感性。
Catecholamine sensitivity in hyperthyroidism and hypothyroidism.
作者信息
McDevitt D G, Riddell J G, Hadden D R, Montgomery D A
出版信息
Br J Clin Pharmacol. 1978 Oct;6(4):297-301. doi: 10.1111/j.1365-2125.1978.tb00855.x.
Abstract
- Catecholamine sensitivity in hyper- and hypothyroidism has been studied using a standardised isoprenaline sensitivity test. 2. Seven patients with hyperthyroidism and seven with hypothyroidism were tested both when showing evidence of thyroid dysfunction and again when euthyroid. 3. No significant differences were seen in heart rate responses to isoprenaline when patients became euthyroid compared to their response when either hyperthyroid or hypothyroid. 4. These results indicate that sensitivity to catecholamines is not altered in thyroid dysfunction and, in particular, that hypersensitivity does not occur in spontaneous hyperthyroidism.
摘要
- 已使用标准化的异丙肾上腺素敏感性试验研究了甲状腺功能亢进和减退时的儿茶酚胺敏感性。2. 7例甲状腺功能亢进患者和7例甲状腺功能减退患者在出现甲状腺功能障碍证据时以及甲状腺功能正常时均接受了测试。3. 与甲状腺功能亢进或减退时相比，患者甲状腺功能正常时对异丙肾上腺素的心率反应未见显著差异。4. 这些结果表明，甲状腺功能障碍时对儿茶酚胺的敏感性未改变，特别是在自发性甲状腺功能亢进时不会出现超敏反应。
相似文献
1
Catecholamine sensitivity in hyperthyroidism and hypothyroidism.甲状腺功能亢进和减退时的儿茶酚胺敏感性。
Br J Clin Pharmacol. 1978 Oct;6(4):297-301. doi: 10.1111/j.1365-2125.1978.tb00855.x.
2
The influence of thyroid states upon responses of the rat aorta to catecholamines.甲状腺状态对大鼠主动脉对儿茶酚胺反应的影响。
Br J Pharmacol. 1990 Mar;99(3):541-7. doi: 10.1111/j.1476-5381.1990.tb12965.x.
3
The effect of isoproterenol on phospholamban-deficient mouse hearts with altered thyroid conditions.异丙肾上腺素对甲状腺状况改变的磷酸受磷蛋白缺陷型小鼠心脏的影响。
J Mol Cell Cardiol. 1999 Sep;31(9):1725-37. doi: 10.1006/jmcc.1999.1010.
4
Plasma protein binding of propranolol and isoprenaline in hyperthyroidism and hypothyroidism.甲状腺功能亢进和减退时普萘洛尔及异丙肾上腺素的血浆蛋白结合情况
Br J Clin Pharmacol. 1978 Aug;6(2):123-7. doi: 10.1111/j.1365-2125.1978.tb00836.x.
5
Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients.甲状腺功能亢进和甲状腺功能减退患者脂肪细胞中脂解作用的肾上腺素能调节
J Clin Endocrinol Metab. 1994 Apr;78(4):898-903. doi: 10.1210/jcem.78.4.8157718.
6
Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice.老年小鼠甲状腺功能亢进和甲状腺功能减退的性别特异性表型。
Biol Sex Differ. 2017 Dec 22;8(1):38. doi: 10.1186/s13293-017-0159-1.
7
Relationship between liver function tests and thyroid hormones in thyroid disorders.甲状腺疾病中肝功能检查与甲状腺激素之间的关系。
Niger Postgrad Med J. 2013 Sep;20(3):188-92.
8
The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients.甲状腺功能减退和甲状腺功能亢进患者脂肪组织中利钠肽和儿茶酚胺诱导的脂肪分解及相关基因的表达
Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E246-51. doi: 10.1152/ajpendo.00688.2006. Epub 2007 Mar 27.
9
Relationship between thyroid functions and urinary growth hormone secretion in patients with hyper- and hypothyroidism.甲状腺功能亢进和减退患者甲状腺功能与尿生长激素分泌之间的关系。
Endocr J. 1994 Oct;41(5):517-22. doi: 10.1507/endocrj.41.517.
10
Effects of thyroid function on submaxillary gland sensitivity to autonomic nervous drugs.甲状腺功能对颌下腺对自主神经药物敏感性的影响。
J Endocrinol Invest. 1982 Jan-Feb;5(1):5-11. doi: 10.1007/BF03350475.
引用本文的文献
1
Short-term variability of blood pressure and heart rate in hyperthyroidism.甲状腺功能亢进症患者血压和心率的短期变异性
Clin Auton Res. 1998 Jun;8(3):181-6. doi: 10.1007/BF02281123.
2
Thyroid hormone modulates inotropic responses, alpha-adrenoceptor density and catecholamine concentrations in the rat heart.甲状腺激素调节大鼠心脏的变力反应、α-肾上腺素能受体密度和儿茶酚胺浓度。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Dec;354(6):755-64. doi: 10.1007/BF00166902.
3
Absence of changes in drug disposition and catecholamine sensitivity in the hyperthyroid dog.甲状腺功能亢进犬的药物处置和儿茶酚胺敏感性无变化。
Br J Pharmacol. 1980;71(1):143-55. doi: 10.1111/j.1476-5381.1980.tb10919.x.
4
Pharmacokinetics and pharmacodynamics of propranolol stereoisomers in hyperthyroid patients.普萘洛尔立体异构体在甲状腺功能亢进患者中的药代动力学和药效学。
Eur J Clin Pharmacol. 1981 Feb;19(3):197-203. doi: 10.1007/BF00561949.
5
Airway response to inhaled salbutamol in hyperthyroid and hypothyroid patients before and after treatment.甲状腺功能亢进和甲状腺功能减退患者治疗前后对吸入沙丁胺醇的气道反应。
Thorax. 1984 Jan;39(1):34-9. doi: 10.1136/thx.39.1.34.
6
Quantitative changes in beta-adrenergic responses of isolated atria from hyper- and hypothyroid rats.甲状腺功能亢进和减退大鼠离体心房β-肾上腺素能反应的定量变化。
Experientia. 1981 Apr 15;37(4):399-401. doi: 10.1007/BF01959885.
7
Influence of thyroid dysfunction on drug pharmacokinetics.甲状腺功能障碍对药物药代动力学的影响。
Clin Pharmacokinet. 1981 Jul-Aug;6(4):275-97. doi: 10.2165/00003088-198106040-00003.
8
Use of beta-adrenoceptor blocking drugs in hyperthyroidism.β-肾上腺素能受体阻断药在甲状腺功能亢进症中的应用。
Drugs. 1984 May;27(5):425-46. doi: 10.2165/00003495-198427050-00003.
9
Clinical pharmacokinetics of beta-adrenoceptor blocking drugs in thyroid disease.β-肾上腺素受体阻断药在甲状腺疾病中的临床药代动力学
Clin Pharmacokinet. 1983 Jan-Feb;8(1):1-16. doi: 10.2165/00003088-198308010-00001.
10
Adrenoceptor blocking drugs: clinical pharmacology and therapeutic use.肾上腺素能受体阻断药：临床药理学与治疗应用
Drugs. 1979 Apr;17(4):267-88. doi: 10.2165/00003495-197917040-00002.
本文引用的文献
1
THE EFFECT OF THYROXIN, CORTICOSTEROIDS, AND EPINEPHRINE ON ATRIAL RATE.
J Pharmacol Exp Ther. 1965 Apr;148:75-9.
2
ADRENAL MEDULLARY AND THYROID RELATIONSHIPS.肾上腺髓质与甲状腺的关系。
Physiol Rev. 1964 Apr;44:161-85. doi: 10.1152/physrev.1964.44.2.161.
3
Role of the autonomic nervous system in the resting tachycardia of experimental hyperthyroidism.自主神经系统在实验性甲状腺功能亢进静息性心动过速中的作用。
J Pharmacol Exp Ther. 1967 Oct;158(1):55-65.
4
The effects of triiodothyronine on hemodynamic responses to epinephrine and norepinephrine in man.三碘甲状腺原氨酸对人体肾上腺素和去甲肾上腺素血流动力学反应的影响。
J Pharmacol Exp Ther. 1967 Jul;157(1):62-8.
5
An experimental evaluation of the reputed influence of thyroxine on the cardiovascular effects of catecholamines.关于甲状腺素对儿茶酚胺心血管效应的所谓影响的实验评估。
J Pharmacol Exp Ther. 1965 Sep;149(3):336-45.
6
The effects of injected norepinephrine and sympathetic nerve stimulation in hypothyroid and hyperthyroid dogs.
J Pharmacol Exp Ther. 1965 Sep;149(3):329-35.
7
Thyroid-catecholamine interrelations.甲状腺-儿茶酚胺相互关系
Annu Rev Med. 1966;17:123-32. doi: 10.1146/annurev.me.17.020166.001011.
8
Intravenously administered isoproterenol sulfate dose-response curves in man.人体静脉注射硫酸异丙肾上腺素的剂量-反应曲线。
Arch Intern Med. 1972 Sep;130(3):361-4.
9
A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranolol.一项标准化的异丙肾上腺素敏感性试验。窦性心律失常、阿托品和普萘洛尔的作用。
Arch Intern Med. 1972 Jul;130(1):47-52. doi: 10.1001/archinte.130.1.47.
10
Studies of the reputed augmentation of the cardiovascular effects of catecholamines in patients with spontaneous hyperthyroidism.对自发性甲状腺功能亢进患者体内儿茶酚胺心血管效应增强的相关研究。
J Pharmacol Exp Ther. 1972 May;181(2):362-8.
Zotero 插件