Murao K, Takahara J, Sato M, Tamaki M, Niimi M, Ishida T
First Department of Internal Medicine, Kagawa Medical School, Japan.
Endocr J. 1994 Oct;41(5):517-22. doi: 10.1507/endocrj.41.517.
Thyroid hormone plays an important role in growth hormone (GH) synthesis and secretion. To study the relationship between thyroid function and urinary GH secretion in the hyperthyroid and hypothyroid states, we measured thyroid hormones, simultaneously with serum and urinary GH levels, in 54 patients with thyroid diseases. GH-releasing hormone (GRH) test was performed in 18 patients in order to evaluate serum and urinary GH responses to GRH in hyper- and hypothyroid states. Serum thyroid hormone levels were strongly correlated with the urinary GH levels in the patients, and the correlation was greater than that between serum thyroid hormone and serum GH levels. Urinary GH levels were significantly higher in the hyperthyroid patients than in the euthyroid and hypothyroid patients, although serum GH levels were not significantly different among these three groups. Serum GH response to GRH was significantly decreased in hyperthyroid patients as compared to euthyroid patients. However, urinary GH levels after GRH administration were not decreased in the hyperthyroid patients. These results suggest that hyperthyroid states increase GH in urine and may accelerate the urinary clearance of GH.
甲状腺激素在生长激素（GH）的合成与分泌中发挥着重要作用。为研究甲状腺功能亢进和减退状态下甲状腺功能与尿GH分泌之间的关系，我们对54例甲状腺疾病患者同时测定了甲状腺激素以及血清和尿GH水平。对18例患者进行了生长激素释放激素（GRH）试验，以评估甲状腺功能亢进和减退状态下血清和尿GH对GRH的反应。患者血清甲状腺激素水平与尿GH水平密切相关，且这种相关性大于血清甲状腺激素与血清GH水平之间的相关性。甲状腺功能亢进患者的尿GH水平显著高于甲状腺功能正常和减退的患者，尽管这三组患者的血清GH水平无显著差异。与甲状腺功能正常的患者相比，甲状腺功能亢进患者对GRH的血清GH反应显著降低。然而，甲状腺功能亢进患者在给予GRH后尿GH水平并未降低。这些结果表明，甲状腺功能亢进状态会增加尿中的GH，并可能加速GH的尿清除率。
