Heideman M, Saravis C, Clowes G H
J Trauma. 1982 Jul;22(7):527-32. doi: 10.1097/00005373-198207000-00001.
Complement concentrations and blood cultures were compared in 58 patients within 24 hours of injury and weekly thereafter. Extensive amounts of nonviable tissue (n = 40) were associated with a mean depletion of C4, C3, and C5 by 56%, and minor injuries (n = 18) by 22% of normal concentration within 14 hours after injury. The C4, C3, and C5 concentrations returned to normal or above within a week after minor injuries, but not following major injuries. However, C4, c3, and C5 levels remained depressed after major injuries unless necrotic tissue was removed or abscesses were drained. If complement concentration was below 50% of normal for more than a week all patients developed bacteremia. Following debridement or drainage complement returned to normal in 11 patients and blood cultures became negative in seven. Possible consequences by activation and altered availability of complement for chemotaxis, opsonization, and lysis of bacteria have been analyzed and related to the development of bacteremia.
对58例患者在受伤后24小时内及之后每周进行补体浓度和血培养比较。大量失活组织（n = 40）与伤后14小时内C4、C3和C5平均耗竭56%相关，轻伤（n = 18）则与正常浓度的22%耗竭相关。轻伤后一周内C4、C3和C5浓度恢复正常或高于正常，但重伤后未恢复。然而，重伤后C4、C3和C5水平仍处于低水平，除非坏死组织被清除或脓肿被引流。如果补体浓度低于正常水平的50%超过一周，所有患者都会发生菌血症。清创或引流后，11例患者补体恢复正常，7例患者血培养转阴。分析了补体激活和可用性改变对趋化作用、调理作用及细菌溶解的可能影响，并将其与菌血症的发生相关联。
