Kapp A, Schöpf E
Acta Derm Venereol Suppl (Stockh). 1985;114:152-4. doi: 10.2340/00015555114152154.
There is little information about the role of complement in atopic dermatitis (AD). We studied the levels of both normal complement components and activation products in peripheral blood of patients with mild to intermediate disease. 35 patients had not received systemic or topical steroid therapy 6 weeks prior to blood collection. C3, C4 and C1 INA were determined in serum by radioimmunodiffusion. C3a and C5a levels were measured in EDTA plasma by radioimmunoassay. Compared to healthy non-atopic controls C3, C4 and C1 INA were found to be increased significantly. There was a tendency towards increased C3a levels but the difference was not significant. No measurable amounts of C5a were detected. Elevations of C3a were correlated with elevated levels of C3. The results suggest that the complement system participates in the inflammatory process in AD.
关于补体在特应性皮炎（AD）中的作用，目前所知甚少。我们研究了轻至中度病情患者外周血中正常补体成分和激活产物的水平。35名患者在采血前6周未接受全身或局部类固醇治疗。通过放射免疫扩散法测定血清中的C3、C4和C1 INA。通过放射免疫分析法测定EDTA血浆中的C3a和C5a水平。与健康的非特应性对照相比，发现C3、C4和C1 INA显著升高。C3a水平有升高的趋势，但差异不显著。未检测到可测量的C5a量。C3a的升高与C3水平的升高相关。结果表明补体系统参与了AD的炎症过程。
