偶氮染料诱导肝癌发生过程中质子磁共振弛豫时间的双相变化。

Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.

作者信息

Kodama M, Ohki T, Saitô H, Nagata C, Tagashira Y

出版信息

Br J Cancer. 1978 Aug;38(2):233-6. doi: 10.1038/bjc.1978.193.

DOI:10.1038/bjc.1978.193

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009704/

Abstract

For the first time, change in the proton longitudinal relaxation times (T1) of rat tissues has been examined throughout the whole process of azo-dye hepatocarcinogenesis. Two maxima of the T1 values were observed for liver, on Day 60 and after Day 120, and these changes correlated well with the changes in water content. The first peak was ascribed to the immature hepatocytes of hyperplastic nodules, and the second peak to the developed hepatoma cells. The significance of the change in T1 values as a preneoplastic change is discussed.

摘要

首次在偶氮染料诱导大鼠肝癌发生的全过程中，对大鼠组织的质子纵向弛豫时间（T1）变化进行了研究。在第60天和120天之后，肝脏的T1值出现两个最大值，这些变化与含水量的变化密切相关。第一个峰值归因于增生性结节中的未成熟肝细胞，第二个峰值归因于成熟的肝癌细胞。文中讨论了T1值变化作为肿瘤前变化的意义。

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J Natl Cancer Inst. 1974 Feb;52(2):353-6. doi: 10.1093/jnci/52.2.353.

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