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Br J Cancer. 1978 Aug;38(2):233-6. doi: 10.1038/bjc.1978.193.
2
Proton NMR studies of tissue water phases during chemical carcinogenesis in rats.大鼠化学致癌过程中组织水相的质子核磁共振研究。
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Cell specificity of rat cytokeratin p39 during azo dye-induced hepatocarcinogenesis.大鼠细胞角蛋白p39在偶氮染料诱导的肝癌发生过程中的细胞特异性
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Immunocytochemical investigation of alpha-fetoprotein-positive cells in hepatocarcinogenesis and hepatomas induced by 3'-ME-DAB.对3'-甲基-4-二甲基氨基偶氮苯诱导的肝癌发生和肝癌中α-甲胎蛋白阳性细胞的免疫细胞化学研究。
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[Nuclear magnetic resonance investigations of DMBA-induced rat breast cancers--the relationship between tumor doubling times and water proton spin-lattice relaxation times].[二甲基苯并蒽诱导的大鼠乳腺癌的核磁共振研究——肿瘤倍增时间与水质子自旋晶格弛豫时间之间的关系]
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引用本文的文献

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DAB-induced changes in NMR relaxation times, water and iron content of rat tissue.二氨基联苯胺（DAB）诱导的大鼠组织核磁共振弛豫时间、水含量及铁含量的变化。
Br J Cancer. 1980 Jul;42(1):148-52. doi: 10.1038/bjc.1980.212.

本文引用的文献

1
Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.乙硫氨酸、2-乙酰氨基芴及3'-甲基-4-二甲基氨基偶氮苯在大鼠肝脏中诱导产生的早期组织学变化序列的相似性。
Cancer Res. 1956 Feb;16(2):142-8.
2
Tumor detection by nuclear magnetic resonance.通过核磁共振进行肿瘤检测。
Science. 1971 Mar 19;171(3976):1151-3. doi: 10.1126/science.171.3976.1151.
3
Water content and proton spin relaxation time for neoplastic and non-neoplastic tissues from mice and humans.小鼠和人类肿瘤组织与非肿瘤组织的含水量及质子自旋弛豫时间。
J Natl Cancer Inst. 1974 Feb;52(2):353-6. doi: 10.1093/jnci/52.2.353.
4
Nuclear magnetic resonance studies of several experimental and human malignant tumors.几种实验性和人类恶性肿瘤的核磁共振研究。
Cancer Res. 1973 Sep;33(9):2156-60.
5
Human tumors detected by nuclear magnetic resonance.通过核磁共振检测出的人类肿瘤。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1471-3. doi: 10.1073/pnas.71.4.1471.
6
Spin-lattice relaxation times for mixtures of water and gelatin or cotton, compared with normal and malignant tissue.水与明胶或棉花混合物的自旋晶格弛豫时间，与正常组织和恶性组织的比较。
J Natl Cancer Inst. 1974 Sep;53(3):689-90. doi: 10.1093/jnci/53.3.689.
7
Nuclear magnetic resonance studies of cancer. V. Appearance and development of a tumor systemic effect in serum and tissues.癌症的核磁共振研究。V. 肿瘤全身效应在血清和组织中的表现及发展
J Natl Cancer Inst. 1974 Sep;53(3):807-15. doi: 10.1093/jnci/53.3.807.
8
Irreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis.肝癌发生早期大鼠肝脏中出现的肌肉型醛缩酶活性水平升高的不可逆固定。
Cancer Res. 1970 Mar;30(3):743-52.
9
Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data.肝癌产生胚胎血清甲种球蛋白：实验与临床数据综述
Cancer Res. 1968 Jul;28(7):1344-50.
10
Early appearance of embryonic -globulin in rat serum during carcinogenesis with 4-dimethylaminoazobenzene.在4-二甲基氨基偶氮苯致癌过程中大鼠血清中胚胎性球蛋白的早期出现。
Cancer Res. 1971 Sep;31(9):1192-4.

偶氮染料诱导肝癌发生过程中质子磁共振弛豫时间的双相变化。

Biphasic change of proton magnetic relaxation times during azo-dye hepatocarcinogenesis.

作者信息

Kodama M, Ohki T, Saitô H, Nagata C, Tagashira Y

出版信息

Br J Cancer. 1978 Aug;38(2):233-6. doi: 10.1038/bjc.1978.193.

DOI:10.1038/bjc.1978.193
PMID:698037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009704/
Abstract

For the first time, change in the proton longitudinal relaxation times (T1) of rat tissues has been examined throughout the whole process of azo-dye hepatocarcinogenesis. Two maxima of the T1 values were observed for liver, on Day 60 and after Day 120, and these changes correlated well with the changes in water content. The first peak was ascribed to the immature hepatocytes of hyperplastic nodules, and the second peak to the developed hepatoma cells. The significance of the change in T1 values as a preneoplastic change is discussed.

摘要

首次在偶氮染料诱导大鼠肝癌发生的全过程中，对大鼠组织的质子纵向弛豫时间（T1）变化进行了研究。在第60天和120天之后，肝脏的T1值出现两个最大值，这些变化与含水量的变化密切相关。第一个峰值归因于增生性结节中的未成熟肝细胞，第二个峰值归因于成熟的肝癌细胞。文中讨论了T1值变化作为肿瘤前变化的意义。