氨苄西林、阿莫西林和甲氧苄啶-磺胺甲恶唑混悬液在中耳炎患儿中的耐受性比较
Comparative tolerability of ampicillin, amoxicillin, and trimethoprim-sulfamethoxazole suspensions in children with otitis media.
作者信息
Feder H M
出版信息
Antimicrob Agents Chemother. 1982 Mar;21(3):426-7. doi: 10.1128/AAC.21.3.426.
The tolerabilities of ampicillin, amoxicillin, and trimethoprim-sulfamethoxazole (TMP-SMX) suspensions were evaluated in 263 children with otitis media. Because of watery stools, therapy was discontinued in 6 of 83 patients treated with ampicillin, in none of 89 patients treated with amoxicillin (P less than 0.01), and in 1 of 91 patients treated with TMP-SMX (P less than 0.03). Of the patients who completed the treatment courses, 13 recipients of ampicillin suffered loose or watery stools for 4 or more days, compared with 6 of the amoxicillin recipients (P less than 0.04) and 5 of the TMP-SMX recipients (P less than 0.02). Thus, ampicillin was clearly less well tolerated than either amoxicillin or TMP-SMX.
对263例中耳炎患儿使用氨苄西林、阿莫西林和复方磺胺甲恶唑（TMP-SMX）混悬液的耐受性进行了评估。因出现水样便，83例接受氨苄西林治疗的患者中有6例中断治疗，89例接受阿莫西林治疗的患者中无1例中断治疗（P<0.01），91例接受TMP-SMX治疗的患者中有1例中断治疗（P<0.03）。在完成治疗疗程的患者中，13例接受氨苄西林治疗的患者出现稀便或水样便持续4天或更长时间，而接受阿莫西林治疗的患者中有6例出现这种情况（P<0.04），接受TMP-SMX治疗的患者中有5例出现这种情况（P<0.02）。因此，氨苄西林的耐受性明显低于阿莫西林或TMP-SMX。
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