Campbell G H, Esser K M, Phillips S M
J Immunol. 1982 Sep;129(3):1272-4.
C57BL/6J mice were immunized with irradiated Trypanosoma rhodesiense organisms. Splenic lymphocytes were subsequently obtained from immunized animals and were tested for blast transformation in vitro after exposure to soluble trypanosome antigens. Immune T lymphocytes were found to be the cells responsible for antigen-mediated blastogenesis to trypanosome antigens. In addition, trypanosome antigen preparations in higher concentrations stimulated B lymphocytes obtained from normal nonimmunized animals.
用经辐照的罗德西亚锥虫对C57BL/6J小鼠进行免疫。随后从免疫动物中获取脾淋巴细胞，并在暴露于可溶性锥虫抗原后在体外检测其母细胞转化情况。发现免疫T淋巴细胞是负责对锥虫抗原进行抗原介导的母细胞生成的细胞。此外，较高浓度的锥虫抗原制剂刺激了从正常未免疫动物中获得的B淋巴细胞。
