Meretey K, Falus A, Erhardt C C, Maini R N
Ann Rheum Dis. 1982 Aug;41(4):405-8. doi: 10.1136/ard.41.4.405.
The sera of 21 patients with rheumatoid arthritis (RA), 11 patients with systemic lupus erythematosus (SLE), and 20 healthy subjects were analysed for the presence of IgE in immune complex fractions. These fractions were isolated by polyethylene glycol precipitation and gel filtration. Thirteen sera from RA patients contained IgE immune complexes (IC) and 11 of these were from patients with extra-articular manifestations. One SLE and none of the control sera contained such material. The serum IgE level did not correlate with IgE content of the IC fractions. Higher mean serum IgE levels were found in RA patients with extra-articular complications than in controls or RA patients with joint disease only, but the differences did not reach statistical significance. IgE anti-rabbit IgG (IgE rheumatoid factors) could be demonstrated in some IgE positive IC fractions. Antibodies to IgE, in 2 instances characterised as belonging to IgG class, were also found in ICs. This suggests the presence of anti IgE complexes. It is suggested that IgE, including some with rheumatoid factor activity, is contained in complexes which may be involved in some extra-articular manifestations of RA.
对21例类风湿性关节炎（RA）患者、11例系统性红斑狼疮（SLE）患者和20名健康受试者的血清进行分析，以检测免疫复合物组分中IgE的存在情况。这些组分通过聚乙二醇沉淀和凝胶过滤分离。13份RA患者的血清含有IgE免疫复合物（IC），其中11份来自有关节外表现的患者。1份SLE患者的血清和所有对照血清均不含此类物质。血清IgE水平与IC组分中的IgE含量无相关性。有关节外并发症的RA患者的平均血清IgE水平高于对照组或仅患关节疾病的RA患者，但差异无统计学意义。在一些IgE阳性的IC组分中可检测到IgE抗兔IgG（IgE类风湿因子）。在IC中还发现了2例被鉴定为属于IgG类的抗IgE抗体。这表明存在抗IgE复合物。提示IgE，包括一些具有类风湿因子活性的IgE，存在于可能与RA的一些关节外表现有关的复合物中。
