Haig D M, McKee T A, Jarrett E E, Woodbury R, Miller H R
Nature. 1982 Nov 11;300(5888):188-90. doi: 10.1038/300188a0.
The connective tissue of rats, and several other species of mammals, contains two distinct types of mast cells that differ in morphology, histochemical staining properties and location1. One type, frequently called the normal connective tissue mast cell, can be obtained in nearly homogeneous preparation from a mixed cell population in the peritoneal cavity and forms the basis of our knowledge of mast cells. The other type is referred to as the mucosal mast cell because in normal rats it has been observed only in mucosal tissue. Infection with helminth parasites induces an exteNsive accumulation of mast cells and eosinophils in the tissues, and parasites of mucous surfaces, in particular, stimulate a rapid hyperplasia of mucosal mast cells. However, the origin of mucosal mast cells, and their relationship to the connective tissue mast cells is uncertain. We now slow that lymphocytes of helminth-infected rats, on in vitro stimulation with specific antigen, release factors causing pronounced mucosal mastocytosis in normal rat bone marrow cultures.
大鼠以及其他几种哺乳动物的结缔组织含有两种不同类型的肥大细胞，它们在形态、组织化学染色特性和位置上存在差异。一种类型，常被称为正常结缔组织肥大细胞，可从腹腔中的混合细胞群体中获得几乎同质的制剂，构成了我们对肥大细胞认识的基础。另一种类型被称为黏膜肥大细胞，因为在正常大鼠中仅在黏膜组织中观察到。感染蠕虫寄生虫会导致组织中肥大细胞和嗜酸性粒细胞大量积聚，尤其是黏液表面的寄生虫会刺激黏膜肥大细胞迅速增生。然而，黏膜肥大细胞的起源及其与结缔组织肥大细胞的关系尚不确定。我们现在发现，感染蠕虫的大鼠淋巴细胞在体外受到特异性抗原刺激时，会释放出导致正常大鼠骨髓培养物中明显黏膜肥大细胞增多的因子。
