老年人群中HLA与年龄之间不存在关联。

Lack of association between HLA and age in an aging population.

作者信息

Blackwelder W C, Mittal K K, McNamara P M, Payne F J

出版信息

Tissue Antigens. 1982 Sep;20(3):188-92. doi: 10.1111/j.1399-0039.1982.tb00344.x.

DOI:10.1111/j.1399-0039.1982.tb00344.x

Abstract

In a sample of 228 Framingham Study participants aged 58 to 86 who were typed for HLA, neither frequencies of individual antigens nor heterozygosity at the A or B loci appeared to be related to age. Previously found associations could be chance occurrences, or HLA-related effects on longevity in the general population might be small. It is also possible that such effects occur at younger ages than those included in our study or that HLA is related to the aging process in a way that is detectable only at very advanced ages.

摘要

在228名年龄在58至86岁之间接受HLA分型的弗雷明汉姆研究参与者样本中，单个抗原的频率以及A或B位点的杂合性似乎均与年龄无关。先前发现的关联可能是偶然发生的，或者HLA对普通人群寿命的影响可能很小。也有可能这种影响发生在比我们研究中所涵盖的年龄更小的时候，或者HLA与衰老过程的关联方式只有在非常高龄时才能检测到。