Mendelman P M, Roberts M C, Smith A L
Antimicrob Agents Chemother. 1982 Sep;22(3):531-3. doi: 10.1128/AAC.22.3.531.
Twenty-two susceptible strains of Haemophilus influenzae were examined for mutation to rifampin resistance (minimal inhibitory concentration, greater than or equal to 10 micrograms/ml). All strains had detectable apparent mutation frequencies with a median minimal inhibitory concentration 2,000-fold greater than that of their wild-type parents. Of the type b strain mutants, 80% (8 of 10) expressed high-level resistance (minimal inhibitory concentration, 750 micrograms/ml) that was 75-fold greater than readily achievable serum concentrations.
对22株流感嗜血杆菌敏感菌株进行了耐利福平突变检测（最低抑菌浓度，大于或等于10微克/毫升）。所有菌株均具有可检测到的明显突变频率，其最低抑菌浓度中位数比其野生型亲本高2000倍。在b型菌株突变体中，80%（10株中的8株）表现出高水平耐药（最低抑菌浓度，750微克/毫升），这比血清中容易达到的浓度高75倍。
