Reinherz E L, Meuer S, Fitzgerald K A, Hussey R E, Levine H, Schlossman S F
Cell. 1982 Oct;30(3):735-43. doi: 10.1016/0092-8674(82)90278-1.
Four distinct surface molecules on human T cells are defined by the monoclonal antibodies anti-T1, anti-T3 (anti-T3A), anti-T11 and anti-T12. Following cell binding, anti-T3 (anti-T3A) and anti-T1 induce independent modulation of their respective ligands, whereas anti-T11 and anti-T12 do not. To explore the biological consequences of this modulation, we used cloned populations of T4 and T8 cytotoxic T lymphocytes. Anti-T3 (anti-T3A), but not anti-T1, inhibits cytotoxic T lymphocyte effector function by T4 and T8 clones as well as antigen-specific T cell recognition. The latter is not secondary to a generalized inhibitory effect since responsiveness to interleukin 2 is maintained. Moreover, after modulation, cytotoxic T lymphocytes recover cytolytic function in parallel with reexpression of surface T3 molecules. We provide evidence for a direct linkage between antigen recognition by T lymphocytes and surface expression of the T3 molecular complex.
抗-T1、抗-T3（抗-T3A）、抗-T11和抗-T12这几种单克隆抗体可识别出人类T细胞上四种不同的表面分子。细胞结合后，抗-T3（抗-T3A）和抗-T1可分别独立调节其各自的配体，而抗-T11和抗-T12则不能。为了探究这种调节的生物学后果，我们使用了T4和T8细胞毒性T淋巴细胞的克隆群体。抗-T3（抗-T3A）而非抗-T1可抑制T4和T8克隆的细胞毒性T淋巴细胞效应功能以及抗原特异性T细胞识别。后者并非继发于普遍的抑制作用，因为对白细胞介素2的反应性得以维持。此外，调节后，细胞毒性T淋巴细胞的溶细胞功能恢复与表面T3分子的重新表达同步。我们提供了证据表明T淋巴细胞的抗原识别与T3分子复合物的表面表达之间存在直接联系。
